Institute of Biomaterial, Department of Applied Chemistry, College of Science, South China Agricultural University, Guangzhou 510642, China.
Research Center of Translational Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China.
Colloids Surf B Biointerfaces. 2015 Jun 1;130:278-86. doi: 10.1016/j.colsurfb.2015.04.026. Epub 2015 Apr 20.
The aim of this study was to synthesis drug-loaded fibrous membrane scaffolds for potential applications as wound dressing. Polyvinylidene fluoride (PVDF) fibrous membranes were loaded with enrofloxacin (Enro) drugs by using an electrospinning process, and their mechanical strength, drug release profile and anti-bacterial properties were evaluated. Enro drug-loaded PVDF membranes exhibited good elasticity, flexibility and excellent mechanical strength. The electrospinning Enro/PVDF membranes showed a burst drug release in the initial 12h, followed by sustained release for the next 3 days, which was an essential property for antibiotic drugs applied for wound healing. The drug-loaded PVDF fibrous membranes displayed excellent anti-bacterial activity toward Escherichia coli and Staphylococcus aureus. The results suggest that electrospinning PVDF membrane scaffolds loaded with drugs can be used as wound dressing.
本研究旨在合成载药纤维膜支架，以作为潜在的伤口敷料。通过静电纺丝工艺将恩诺沙星（Enro）药物负载到聚偏二氟乙烯（PVDF）纤维膜上，并对其机械强度、药物释放特性和抗菌性能进行了评估。载有 Enro 的 PVDF 膜具有良好的弹性、柔韧性和优异的机械强度。静电纺丝载 Enro/PVDF 膜在前 12 小时内表现出快速药物释放，随后在接下来的 3 天内持续释放，这是用于伤口愈合的抗生素药物的重要特性。载药 PVDF 纤维膜对大肠杆菌和金黄色葡萄球菌表现出优异的抗菌活性。结果表明，负载药物的静电纺丝 PVDF 膜支架可用作伤口敷料。
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