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在西非贝宁一个城市地区生活的孕妇中,基孔肯雅病毒抗体的血清阳性率很高。

High seroprevalence of chikungunya virus antibodies among pregnant women living in an urban area in Benin, West Africa.

作者信息

Bacci Anastasia, Marchi Serena, Fievet Nadine, Massougbodji Achille, Perrin Renè Xavier, Chippaux Jean-Philippe, Sambri Vittorio, Landini Maria Paola, Varani Stefania, Rossini Giada

机构信息

Unit of Clinical Microbiology, Regional Reference Centre for Microbiological Emergencies (CRREM), St. Orsola-Malpighi University Hospital, Bologna, Italy; Centre d'étude et de Recherche sur le Paludisme Associé à la Grossesse et à l'Enfance (CERPAGE), Faculté des Sciences de la Santé, Université d'Abomey-Calavi, Benin; Institut de Recherche pour le Développement, Unitès mixtes de Recherche (UMR) 216, Mère et Enfant Face aux Infections Tropicales, France; Pres Sorbonne Paris Cité, Université Paris Descartes, Faculté de Pharmacie, Paris, France; Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy; Unit of Microbiology, Area Vasta Romagna (AVR), Pievesestina, Cesena, Italy.

Unit of Clinical Microbiology, Regional Reference Centre for Microbiological Emergencies (CRREM), St. Orsola-Malpighi University Hospital, Bologna, Italy; Centre d'étude et de Recherche sur le Paludisme Associé à la Grossesse et à l'Enfance (CERPAGE), Faculté des Sciences de la Santé, Université d'Abomey-Calavi, Benin; Institut de Recherche pour le Développement, Unitès mixtes de Recherche (UMR) 216, Mère et Enfant Face aux Infections Tropicales, France; Pres Sorbonne Paris Cité, Université Paris Descartes, Faculté de Pharmacie, Paris, France; Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy; Unit of Microbiology, Area Vasta Romagna (AVR), Pievesestina, Cesena, Italy

出版信息

Am J Trop Med Hyg. 2015 Jun;92(6):1133-6. doi: 10.4269/ajtmh.14-0092. Epub 2015 May 4.

Abstract

The aim of this study was to investigate the seroprevalence of antichikungunya virus (anti-CHIKV) antibodies in pregnant women living in an urban area of Benin (West Africa). Results were obtained by screening sera collected in 2006 and 2007 with enzyme-linked immunosorbent assay (ELISA) for anti-CHIKV immunoglobulin G (IgG) and IgM. Positive results were confirmed by indirect immunofluorescence test and microneutralization assay. We found that a large proportion (36.1%) of pregnant women living in Cotonou had specific IgG against CHIKV, indicating a high seroprevalence of the infection in urban southern Benin, whereas no active cases of CHIKV infection were detected.

摘要

本研究旨在调查居住在贝宁(西非)一个城市地区的孕妇中抗基孔肯雅病毒(anti-CHIKV)抗体的血清流行率。通过用酶联免疫吸附测定(ELISA)筛查2006年和2007年收集的血清中的抗CHIKV免疫球蛋白G(IgG)和IgM来获得结果。阳性结果通过间接免疫荧光试验和微量中和试验进行确认。我们发现,居住在科托努的很大一部分(36.1%)孕妇具有针对CHIKV的特异性IgG,这表明在贝宁南部城市地区该感染的血清流行率很高,而未检测到CHIKV感染的活跃病例。

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