与用每只手书写和绘画相关的大脑激活情况。
Cerebral activations related to writing and drawing with each hand.
作者信息
Potgieser Adriaan R E, van der Hoorn Anouk, de Jong Bauke M
机构信息
Department of Neurology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands; Neuroimaging center, University Medical Center, University of Groningen, Groningen, The Netherlands; Department of Neurosurgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Department of Neurology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands; Neuroimaging center, University Medical Center, University of Groningen, Groningen, The Netherlands; Department of Radiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
出版信息
PLoS One. 2015 May 8;10(5):e0126723. doi: 10.1371/journal.pone.0126723. eCollection 2015.
BACKGROUND
Writing is a sequential motor action based on sensorimotor integration in visuospatial and linguistic functional domains. To test the hypothesis of lateralized circuitry concerning spatial and language components involved in such action, we employed an fMRI paradigm including writing and drawing with each hand. In this way, writing-related contributions of dorsal and ventral premotor regions in each hemisphere were assessed, together with effects in wider distributed circuitry. Given a right-hemisphere dominance for spatial action, right dorsal premotor cortex dominance was expected in left-hand writing while dominance of the left ventral premotor cortex was expected during right-hand writing.
METHODS
Sixteen healthy right-handed subjects were scanned during audition-guided writing of short sentences and simple figure drawing without visual feedback. Tapping with a pencil served as a basic control task for the two higher-order motor conditions. Activation differences were assessed with Statistical Parametric Mapping (SPM).
RESULTS
Writing and drawing showed parietal-premotor and posterior inferior temporal activations in both hemispheres when compared to tapping. Drawing activations were rather symmetrical for each hand. Activations in left- and right-hand writing were left-hemisphere dominant, while right dorsal premotor activation only occurred in left-hand writing, supporting a spatial motor contribution of particularly the right hemisphere. Writing contrasted to drawing revealed left-sided activations in the dorsal and ventral premotor cortex, Broca's area, pre-Supplementary Motor Area and posterior middle and inferior temporal gyri, without parietal activation.
DISCUSSION
The audition-driven postero-inferior temporal activations indicated retrieval of virtual visual form characteristics in writing and drawing, with additional activation concerning word form in the left hemisphere. Similar parietal processing in writing and drawing pointed at a common mechanism by which such visually formatted information is used for subsequent sensorimotor integration along a dorsal visuomotor pathway. In this, the left posterior middle temporal gyrus subserves phonological-orthographical conversion, dissociating dorsal parietal-premotor circuitry from perisylvian circuitry including Broca's area.
背景
书写是一种基于视觉空间和语言功能领域中感觉运动整合的连续运动动作。为了检验关于此类动作中涉及的空间和语言成分的偏侧化神经回路的假设，我们采用了一种功能磁共振成像（fMRI）范式，包括用每只手进行书写和绘图。通过这种方式，评估了每个半球背侧和腹侧运动前区与书写相关的贡献，以及更广泛分布的神经回路中的效应。鉴于右半球在空间动作上占优势，预计左手书写时右背侧运动前皮质占优势，而右手书写时左腹侧运动前皮质占优势。
方法
对16名健康的右利手受试者在听觉引导下书写短句和简单图形绘制且无视觉反馈的过程中进行扫描。用铅笔轻敲作为两种高级运动条件的基本对照任务。使用统计参数映射（SPM）评估激活差异。
结果
与轻敲相比，书写和绘图在两个半球均显示顶叶-运动前区和颞叶后下部激活。每只手的绘图激活相当对称。左手和右手书写时的激活以左半球为主，而右背侧运动前区激活仅出现在左手书写中，支持特别是右半球的空间运动贡献。书写与绘图的对比显示，背侧和腹侧运动前皮质、布洛卡区、补充运动前区以及颞中回和颞下回后部左侧激活，无顶叶激活。
讨论
听觉驱动的颞叶后下部激活表明在书写和绘图中检索虚拟视觉形式特征，左半球还有关于单词形式的额外激活。书写和绘图中类似的顶叶处理表明存在一种共同机制，通过该机制这种视觉格式化信息用于沿背侧视觉运动通路进行后续的感觉运动整合。在这方面，左颞中回后部参与语音-正字法转换，使背侧顶叶-运动前神经回路与包括布洛卡区在内的颞周神经回路分离。
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