van Bodegom P C, Wagenaar S S, Corrin B, Baak J P, Berkel J, Vanderschueren R G
Department of Pathology, St Antonius Hospital, Nieuwegein, The Netherlands.
Thorax. 1989 Oct;44(10):788-93. doi: 10.1136/thx.44.10.788.
Review of histopathological and clinical data showed that 153 patients at one hospital developed a second primary lung cancer during 1980-6, 10% of all those with lung carcinoma. There were 64 synchronous tumours (interval less than one year) and 89 metachronous tumours (interval over one year). The average interval between metachronous tumours was 6.1 years. The criteria for diagnosing a second primary lung cancer were any of the following: (1) different histological type; (2) different lobe; (3) interval between the two tumours of at least three years. The incidence of second primary tumours increases with survival, and close follow up is required for their early detection.
对组织病理学和临床数据的回顾显示,一家医院的153名患者在1980年至1986年期间发生了第二原发性肺癌,占所有肺癌患者的10%。有64例同步肿瘤(间隔时间少于一年)和89例异时肿瘤(间隔时间超过一年)。异时肿瘤之间的平均间隔时间为6.1年。诊断第二原发性肺癌的标准如下:(1)不同的组织学类型;(2)不同的肺叶;(3)两个肿瘤之间的间隔至少三年。第二原发性肿瘤的发病率随生存率增加,需要密切随访以早期发现。