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在初次吊带手术失败的病例中,人工尿道括约肌优于二次经闭孔男性吊带。

The Artificial Urinary Sphincter is Superior to a Secondary Transobturator Male Sling in Cases of a Primary Sling Failure.

作者信息

Ajay Divya, Zhang Haijing, Gupta Shubham, Selph John P, Belsante Michael J, Lentz Aaron C, Webster George D, Peterson Andrew C

机构信息

Division of Urology, Department of Surgery, Duke University Medical Center, Durham, North Carolina.

School of Medicine, Duke University Medical Center, Durham, North Carolina.

出版信息

J Urol. 2015 Oct;194(4):1038-42. doi: 10.1016/j.juro.2015.04.106. Epub 2015 May 9.

Abstract

PURPOSE

We compared continence outcomes in patients with post-prostatectomy stress urinary incontinence treated with a salvage artificial urinary sphincter vs a secondary transobturator sling.

MATERIALS AND METHODS

We retrospectively reviewed the records of patients undergoing salvage procedures after sling failure from 2006 to 2012. Postoperative success was defined as the use of 0 or 1 pad, a negative stress test and pad weight less than 8 gm per day. We performed the Wilcoxon test and used a Cox regression model and Kaplan-Meier survival analysis.

RESULTS

A total of 61 men presenting with sling failure were included in study, of whom 32 went directly to an artificial urinary sphincter and 29 received a secondary sling. Of the artificial urinary sphincter cohort 47% underwent prior external beam radiation therapy vs 17% of the secondary sling cohort (p = 0.01). Average preoperative 24 hour pad weight and pad number were higher in the artificial urinary sphincter cohort. Median followup in artificial urinary sphincter and secondary sling cases was 4.5 (IQR 4-12) and 4 months (IQR 1-5), respectively. Overall treatment failure was seen in 55% of patients (16 of 29) with a secondary sling vs 6% (2 of 32) with an artificial urinary sphincter (unadjusted HR 7, 95% CI 2-32 and adjusted HR 6, 95% CI 1-31).

CONCLUSION

In this cohort of patients with post-prostatectomy stress urinary incontinence and a failed primary sling those who underwent a secondary sling procedure were up to 6 times more likely to have persistent incontinence vs those who underwent artificial urinary sphincter placement. These data are useful for counseling patients and planning surgery. We currently recommend placement of an artificial urinary sphincter for patients in whom an initial sling has failed.

摘要

目的

我们比较了接受挽救性人工尿道括约肌治疗与二次经闭孔吊带治疗的前列腺切除术后压力性尿失禁患者的控尿结果。

材料与方法

我们回顾性分析了2006年至2012年吊带治疗失败后接受挽救性手术患者的记录。术后成功定义为每天使用0或1片尿垫、压力试验阴性且尿垫重量小于8克。我们进行了Wilcoxon检验,并使用Cox回归模型和Kaplan-Meier生存分析。

结果

共有61例吊带治疗失败的男性纳入研究,其中32例直接接受人工尿道括约肌治疗,29例接受二次吊带治疗。人工尿道括约肌组47%的患者曾接受过外照射放疗,而二次吊带组为17%(p = 0.01)。人工尿道括约肌组术前平均24小时尿垫重量和尿垫使用数量更高。人工尿道括约肌组和二次吊带组的中位随访时间分别为4.5个月(四分位间距4 - 12)和4个月(四分位间距1 - 5)。二次吊带治疗的患者中有55%(29例中的16例)出现总体治疗失败,而人工尿道括约肌治疗的患者中这一比例为6%(32例中的2例)(未调整的风险比为7,95%置信区间为2 - 32;调整后的风险比为6,95%置信区间为1 - 31)。

结论

在这组前列腺切除术后压力性尿失禁且初次吊带治疗失败的患者中,接受二次吊带手术的患者出现持续性尿失禁的可能性比接受人工尿道括约肌植入术的患者高6倍。这些数据有助于为患者提供咨询和规划手术。我们目前建议,对于初次吊带治疗失败的患者,应植入人工尿道括约肌。

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