打破病原体的“铁意志”：抑制铁载体产生作为一种抗菌策略。
Breaking a pathogen's iron will: Inhibiting siderophore production as an antimicrobial strategy.
作者信息
Lamb Audrey L
机构信息
Department of Molecular Biosciences, University of Kansas, Lawrence, KS 66045, USA.
出版信息
Biochim Biophys Acta. 2015 Aug;1854(8):1054-70. doi: 10.1016/j.bbapap.2015.05.001. Epub 2015 May 10.
Abstract
The rise of antibiotic resistance is a growing public health crisis. Novel antimicrobials are sought, preferably developing nontraditional chemical scaffolds that do not inhibit standard targets such as cell wall synthesis or the ribosome. Iron scavenging has been proposed as a viable target, because bacterial and fungal pathogens must overcome the nutritional immunity of the host to be virulent. This review highlights the recent work toward exploiting the biosynthetic enzymes of siderophore production for the design of next generation antimicrobials.
摘要
抗生素耐药性的上升是一个日益严重的公共卫生危机。人们正在寻找新型抗菌药物，最好是开发不抑制诸如细胞壁合成或核糖体等标准靶点的非传统化学支架。有人提出铁清除作为一个可行的靶点，因为细菌和真菌病原体必须克服宿主的营养免疫才能具有致病性。这篇综述重点介绍了利用铁载体生物合成酶设计下一代抗菌药物的最新研究进展。
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