化学和生化过程中的两种速率决定步骤。
Two types of rate-determining step in chemical and biochemical processes.
作者信息
Yagisawa S
机构信息
Faculty of Pharmaceutical Sciences, University of Nagasaki, Japan.
出版信息
Biochem J. 1989 Nov 1;263(3):985-8. doi: 10.1042/bj2630985.
Close examination of the concept of the rate-determining step (RDS) shows that there are two types of RDS depending on the definition of 'rate'. One is represented by the highest peak of the free-energy diagram of consecutive reactions and holds true where the rate is defined in terms of the concentration of the first reactant. The other is represented by the peak showing the maximum free-energy difference, where the free-energy difference is the height of a peak measured from the bottom of any preceding troughs, where the definition of the rate is in terms of the total reactant concentration including intermediates. There are no criteria a priori for selecting one of them.
对速率决定步骤（RDS）概念的仔细研究表明，根据“速率”的定义，存在两种类型的RDS。一种由连续反应的自由能图的最高峰表示，在速率根据第一种反应物的浓度定义的情况下成立。另一种由显示最大自由能差的峰表示，其中自由能差是从任何先前波谷底部测量的峰的高度，在此速率的定义是基于包括中间体在内的总反应物浓度。没有先验标准来选择其中之一。
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