患有牙周炎和/或冠心病患者的炎性细胞因子水平。
Inflammatory cytokine levels in patients with periodontitis and/or coronary heart disease.
作者信息
Zhu Haihua, Lin Xiaolong, Zheng Pei, Chen Hui
机构信息
Department of Conservative Dentistry and Periodontics, Affiliated Hospital of Stomatology, College of Medicine, Zhejiang University China.
出版信息
Int J Clin Exp Pathol. 2015 Feb 1;8(2):2214-20. eCollection 2015.
Abstract
The purpose of this study was to investigate systemic and local levels of four classic inflammatory cytokines (IL-1β, MCP-1, VEGF, PDGF) in patients with periodontitis and coronary heart disease (CHD). 109 volunteers were enrolled and the condition of their periodontal tissue and coronary artery were assessed. The patients were then divided into four distinct groups: periodontitis only, CHD only, periodontitis with CHD, and healthy controls. Gingival crevicular fluid (GCF) and venous blood were collected. The concentrations of cytokines were detected meanwhile by specific ELISA. The IL-1β and MCP-1 concentrations in the serum and GCF of the three disease groups were significantly higher than those in the control group (P ≤ 0.05). Serum VEGF concentrations of the patients with existing disease was lower than that of the controls. VEGF levels in the GCF of all disease groups were significantly higher than that of the control group (P ≤ 0.05).
摘要
本研究旨在调查牙周炎合并冠心病（CHD）患者体内四种经典炎性细胞因子（IL-1β、MCP-1、VEGF、PDGF）的全身和局部水平。招募了109名志愿者，并对他们的牙周组织和冠状动脉状况进行了评估。然后将患者分为四个不同的组：仅患有牙周炎、仅患有冠心病、患有牙周炎合并冠心病以及健康对照组。收集龈沟液（GCF）和静脉血。同时通过特异性酶联免疫吸附测定（ELISA）检测细胞因子的浓度。三个疾病组血清和GCF中IL-1β和MCP-1的浓度显著高于对照组（P≤0.05）。现有疾病患者的血清VEGF浓度低于对照组。所有疾病组GCF中的VEGF水平显著高于对照组（P≤0.05）。
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