神经元迁移：肌球蛋白结合蛋白保护前缘肌动蛋白。

Neuron migration: anillin protects leading edge actin.

机构信息

(1)Curriculum in Genetics, University of North Carolina, Chapel Hill, NC 27599, USA.

(1)Curriculum in Genetics, University of North Carolina, Chapel Hill, NC 27599, USA; Department of Biology, University of North Carolina, Chapel Hill, NC 27599, USA.

出版信息

Curr Biol. 2015 May 18;25(10):R423-5. doi: 10.1016/j.cub.2015.03.030.

DOI:10.1016/j.cub.2015.03.030

PMID:25989084

Abstract

Establishment of a neuronal system requires proper regulation of the F-actin-rich leading edges of migrating neurons and neurite growth cones. A new study shows that RhoG signals through the multi-domain protein anillin to stabilize F-actin in these structures.

摘要

建立神经元系统需要正确调节迁移神经元和神经突生长锥的富含 F-肌动蛋白的前缘。一项新的研究表明，RhoG 通过多结构域蛋白伴肌动蛋白（anillin）信号传导来稳定这些结构中的 F-肌动蛋白。