铜（II）催化亚磺酸钠与C(sp(2))-H键的直接磺酰化反应
Copper(II)-Catalyzed Direct Sulfonylation of C(sp(2))-H Bonds with Sodium Sulfinates.
作者信息
Rao Wei-Hao, Shi Bing-Feng
机构信息
Department of Chemistry, Zhejiang University, Hangzhou 310027, China.
出版信息
Org Lett. 2015 Jun 5;17(11):2784-7. doi: 10.1021/acs.orglett.5b01198. Epub 2015 May 20.
PMID:25992710
Abstract
A copper-catalyzed direct sulfonylation of C(sp(2))-H bonds with sodium sulfinates using a removable directing group is described. This reaction tolerates a wide range of functional groups, providing an efficient protocol for the synthesis of diverse aryl sulfones. Moreover, a series of 2,6-disubstituted benzamides could be synthesized via sequential C-H functionalization.
摘要
描述了一种使用可去除导向基团通过铜催化的C(sp(2))-H键与亚磺酸钠直接进行磺酰化反应。该反应能耐受多种官能团，为合成各种芳基砜提供了一种有效的方法。此外，一系列2,6-二取代苯甲酰胺可通过连续的C-H官能化反应合成。
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