Quan Kecheng, Li Guofeng, Luan Di, Yuan Qipeng, Tao Lei, Wang Xing
The State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing 100029, PR China.
The Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084, PR China.
Colloids Surf B Biointerfaces. 2015 Aug 1;132:27-33. doi: 10.1016/j.colsurfb.2015.04.067. Epub 2015 May 11.
In this study, we demonstrate for the first time the remarkable hemostatic performance of a cross-linked graphene sponge (CGS) as a superb hemostat. The CGS can absorb plasma immediately (<40 ms) to form a blood cell layer and promotes subsequent clotting. The interaction between the interface of the CGS and blood cells reveals that the fast blood coagulation is primarily attributed to the enrichment of hemocytes and platelets on the wound surface. An in vitro dynamic whole-blood clotting test further highlights the effectiveness of the CGS. Considering the facile preparation, low cost, nontoxicity, and long shelf life of the portable black sponge, the CGS has great potential for trauma treatment.
在本研究中,我们首次展示了交联石墨烯海绵(CGS)作为一种卓越的止血剂所具有的非凡止血性能。CGS能够立即(<40毫秒)吸收血浆以形成血细胞层,并促进随后的凝血过程。CGS与血细胞界面之间的相互作用表明,快速凝血主要归因于伤口表面血细胞和血小板的富集。体外动态全血凝血试验进一步突出了CGS的有效性。考虑到这种便携式黑色海绵制备简便、成本低、无毒且保质期长,CGS在创伤治疗方面具有巨大潜力。