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双特异性抗体、纳米颗粒与细胞：让合适的细胞发挥作用。

Bispecific antibodies, nanoparticles and cells: bringing the right cells to get the job done.

作者信息

Tang Junnan, Shen Deliang, Zhang Jinying, Ligler Frances S, Cheng Ke

机构信息

North Carolina State University, College of Veterinary Medicine, Department of Molecular Biomedical Sciences and Center for Comparative Medicine and Translational Research , Raleigh, NC , USA.

出版信息

Expert Opin Biol Ther. 2015;15(9):1251-5. doi: 10.1517/14712598.2015.1049944. Epub 2015 May 25.

DOI:10.1517/14712598.2015.1049944
PMID:26004388
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4761226/
Abstract

Pre-arming therapeutic cells with bispecific antibodies (BiAbs) before infusion can home the cells to specific tissue antigens in the body. With the development of nanotechnology, we developed a novel strategy, namely magnetic bispecific cell engager (MagBICE), that combines BiAbs with biodegradable iron nanoparticles. Compared to conventional BiAbs, the latter enables magnetic targeting and imaging. This editorial discusses current knowledge of BiAbs and their applications in targeting activated T cells to cancerous tissues or targeting bone marrow-derived stem cells to myocardial infarction. We will also discuss the fabrication of MagBICE and its application in treating rodents with myocardial infarction.

摘要

在输注前用双特异性抗体（BiAbs）对治疗性细胞进行预武装，可使细胞归巢至体内特定的组织抗原。随着纳米技术的发展，我们开发了一种新策略，即磁性双特异性细胞衔接器（MagBICE），它将双特异性抗体与可生物降解的铁纳米颗粒相结合。与传统双特异性抗体相比，后者能够实现磁性靶向和成像。这篇社论讨论了双特异性抗体的当前知识及其在将活化T细胞靶向癌组织或将骨髓来源的干细胞靶向心肌梗死方面的应用。我们还将讨论磁性双特异性细胞衔接器的制备及其在治疗心肌梗死啮齿动物中的应用。

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本文引用的文献

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