Humphries Romney M, Schuetz Audrey N
Pathology & Laboratory Medicine, University of California Los Angeles, 10833 Le Conte Avenue, Brentwood Annex, Los Angeles, CA 90095, USA.
Department of Pathology and Laboratory Medicine, Weill Cornell Medical College/NewYork-Presbyterian Hospital, 525 East 68th Street, Starr 737C, New York, NY 10065, USA.
Clin Lab Med. 2015 Jun;35(2):313-31. doi: 10.1016/j.cll.2015.02.005. Epub 2015 Apr 4.
Gastroenteritis due to enteric pathogens is generally a self-limiting disease for which antimicrobial treatment is not required. However, treatment should be considered for cases of severe or prolonged diarrhea, extraintestinal isolation of bacteria, or diarrhea in immunocompromised hosts, the elderly, and infants. Various resistance trends and current issues concerning antimicrobial susceptibility testing of enteric pathogens are reviewed in this article, including Campylobacter, Salmonella, Shigella, Vibrio, Aeromonas, Plesiomonas, and Clostridium difficile. Updated interpretive criteria from breakpoint-setting organizations are reviewed, along with explanations for recent changes in antimicrobial breakpoints.
由肠道病原体引起的肠胃炎通常是一种自限性疾病,无需进行抗菌治疗。然而,对于严重或持续性腹泻、细菌的肠外分离、免疫功能低下宿主、老年人及婴儿的腹泻病例,应考虑进行治疗。本文综述了肠道病原体抗菌药敏试验的各种耐药趋势和当前问题,包括弯曲杆菌、沙门氏菌、志贺氏菌、弧菌、气单胞菌、邻单胞菌和艰难梭菌。还综述了断点设定组织的最新解释标准,以及抗菌药物断点近期变化的解释。