红海海洋无脊椎动物中萜类化合物的分子结构与生物医学先导物
Molecular architecture and biomedical leads of terpenes from red sea marine invertebrates.
作者信息
Hegazy Mohamed Elamir F, Mohamed Tarik A, Alhammady Montaser A, Shaheen Alaa M, Reda Eman H, Elshamy Abdelsamed I, Aziz Mina, Paré Paul W
机构信息
Chemistry of Medicinal Plants Department, Center of Excellence for Advanced Sciences, National Research Centre, 33 El Bohouth st., Dokki, Giza, P.O. Box 12622, Egypt.
National Institute of Oceanography and Fisheries, Red Sea Branch, Hurghada 84511, Egypt.
出版信息
Mar Drugs. 2015 May 20;13(5):3154-81. doi: 10.3390/md13053154.
Marine invertebrates including sponges, soft coral, tunicates, mollusks and bryozoan have proved to be a prolific source of bioactive natural products. Among marine-derived metabolites, terpenoids have provided a vast array of molecular architectures. These isoprenoid-derived metabolites also exhibit highly specialized biological activities ranging from nerve regeneration to blood-sugar regulation. As a result, intense research activity has been devoted to characterizing invertebrate terpenes from both a chemical and biological standpoint. This review focuses on the chemistry and biology of terpene metabolites isolated from the Red Sea ecosystem, a unique marine biome with one of the highest levels of biodiversity and specifically rich in invertebrate species.
包括海绵、软珊瑚、被囊动物、软体动物和苔藓虫在内的海洋无脊椎动物已被证明是生物活性天然产物的丰富来源。在海洋衍生的代谢产物中，萜类化合物提供了大量的分子结构。这些异戊二烯衍生的代谢产物还表现出高度专业化的生物活性，从神经再生到血糖调节。因此，人们从化学和生物学角度对无脊椎动物萜类进行了深入的研究。本综述重点关注从红海生态系统中分离出的萜类代谢产物的化学和生物学，红海生态系统是一个独特的海洋生物群落，具有最高水平的生物多样性之一，尤其富含无脊椎动物物种。
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