Wes Ari M, Wink Jason D, Kovach Stephen J, Fischer John P
Philadelphia, Pa. From the Division of Plastic Surgery, Hospital of the University of Pennsylvania.
Plast Reconstr Surg. 2015 Jun;135(6):972e-980e. doi: 10.1097/PRS.0000000000001251.
The purpose of this study was to examine the incidence and predictors of venous thromboembolism following body contouring.
The authors reviewed the American College of Surgeons National Surgical Quality Improvement Program database from 2005 to 2012 for all body contouring cases. A multivariate logistic regression was performed to determine predictors of venous thromboembolism, and used to define risk scores for each significant predictor.
Seventeen thousand seven hundred seventy-four patients underwent body contouring during the study period. Venous thromboembolism occurred in 99 individuals (0.56 percent). Multivariate logistic regression revealed that age older than 45 years [45 to 60 years (OR, 1.54; p = 0.1); older than 60 years (OR 3.1, p < 0.001)], undergoing contouring of the trunk (OR, 2.75; p < 0.001), obesity [body mass index of 30 to 34.9 (OR, 3.35; p < 0.001); body mass index of 35 to 39.9 (OR, 4.41; p < 0.001); body mass index ≥ 40 (OR, 3.14; p = 0.001)], and admission on an inpatient basis (OR, 3.01; p < 0.001) were associated with increased odds of venous thromboembolism. Patients' total scores were categorized as low (0 to 4), medium (5 to 7), or high risk (8 to 9). The low-risk cohort exhibited a venous thromboembolism incidence of 0.14 percent, the medium-risk cohort experienced an incidence of 0.97 percent, and the high-risk group experienced a venous thromboembolism incidence of 2.95 percent.
This study identifies predictors of venous thromboembolism and creates a simple risk-scoring model using a large, prospective data set. The authors' analysis demonstrates that in the presence of certain risk factors, the incidence of venous thromboembolism increases dramatically; in these cases, venous thromboembolism prophylaxis may be warranted.
CLINICAL QUESTION/LEVEL OF EVIDENCE: Risk, III.
本研究旨在调查身体塑形术后静脉血栓栓塞症的发生率及预测因素。
作者回顾了美国外科医师学会国家外科质量改进计划数据库中2005年至2012年所有身体塑形病例。进行多因素逻辑回归分析以确定静脉血栓栓塞症的预测因素,并用于为每个显著预测因素定义风险评分。
在研究期间,17774例患者接受了身体塑形手术。99例(0.56%)发生了静脉血栓栓塞症。多因素逻辑回归分析显示,年龄大于45岁[45至60岁(比值比,1.54;p = 0.1);大于60岁(比值比3.1,p < 0.001)]、进行躯干塑形(比值比,2.75;p < 0.001)、肥胖[体重指数为30至34.9(比值比,3.35;p < 0.001);体重指数为35至39.9(比值比,4.41;p < 0.001);体重指数≥40(比值比,3.14;p = 0.001)]以及住院入院(比值比,3.01;p < 0.001)与静脉血栓栓塞症发生几率增加相关。患者的总分分为低风险(0至4分)、中风险(5至7分)或高风险(8至9分)。低风险队列的静脉血栓栓塞症发生率为0.14%,中风险队列发生率为0.97%,高风险组的静脉血栓栓塞症发生率为2.95%。
本研究确定了静脉血栓栓塞症的预测因素,并使用大型前瞻性数据集创建了一个简单的风险评分模型。作者的分析表明,在存在某些风险因素时,静脉血栓栓塞症的发生率会显著增加;在这些情况下,可能有必要进行静脉血栓栓塞症预防。
临床问题/证据级别:风险,III级