传染性病原体和疫苗抗原的免疫原性。
Immunogenicity of infectious pathogens and vaccine antigens.
作者信息
Mahanty Siddhartha, Prigent Antoine, Garraud Olivier
机构信息
Laboratory of Parasitic Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA.
Etablissement Français du Sang (EFS) Auvergne-Loire, 42023, Saint-Etienne, France.
出版信息
BMC Immunol. 2015 May 29;16:31. doi: 10.1186/s12865-015-0095-y.
The concept of the immunogenicity of an antigen is frequently encountered in the context of vaccine development, an area of intense interest currently due to the emergence or re-emergence of infectious pathogens with the potential for worldwide spread. However, the theoretical notion of immunogenicity as discussed in older textbooks of immunology needs reconsideration due to advances in our understanding of immunologic responses. Immunogenicity is a property that can either be a desirable attribute, for example in the generation of an effective protective immunity against infectious pathogens or an undesirable trait, for example when it relates to novel therapeutic compounds and drugs, where an immune response needs to be prevented or inhibited. In this Forum Article, we aimed to revisit the issue of immunogenicity to discuss a series of simple questions relevant to the concept that are frequently rephrased but incompletely resolved in the immunologic literature.
抗原免疫原性的概念在疫苗研发领域经常被提及，目前这是一个备受关注的领域，因为具有全球传播潜力的传染性病原体不断出现或再次出现。然而，鉴于我们对免疫反应理解的进展，免疫学旧教科书中讨论的免疫原性理论概念需要重新审视。免疫原性这一特性既可能是一种理想的属性，例如在产生针对传染性病原体的有效保护性免疫方面；也可能是一种不良特性，例如当它涉及新型治疗化合物和药物时，此时需要预防或抑制免疫反应。在这篇论坛文章中，我们旨在重新审视免疫原性问题，以讨论一系列与该概念相关的简单问题，这些问题在免疫学文献中经常被重新表述但未得到完全解决。
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