雌激素刺激MtT/F4可移植垂体瘤中催乳素和生长激素信使核糖核酸的表达。
Estrogen stimulates both prolactin and growth hormone mRNAs expression in the MtT/F4 transplantable pituitary tumor.
作者信息
Jin L, Song J Y, Lloyd R V
机构信息
Department of Pathology, University of Michigan Medical Center, Ann Arbor 48109.
出版信息
Proc Soc Exp Biol Med. 1989 Dec;192(3):225-9. doi: 10.3181/00379727-192-42989.
The effects of 17 beta-estradiol (E2) on MtT/F4 pituitary tumor growth and on prolactin (PRL) and growth hormone mRNA expression were analyzed in F344 female rats. E2 (10 mg) stimulated pituitary PRL cell hyperplasia and PRL mRNA, but inhibited growth of the transplantable tumors. The expression of both PRL and growth hormone mRNA levels was increased in the MtT/F4 tumors. The effects of E2 on increasing PRL mRNA levels were more marked in the pituitary compared with the tumors. These results indicate that estrogens stimulate proliferation and PRL expression in the pituitary while inhibiting cell proliferation in the MtT/F4 tumor. E2 also stimulated both growth hormone and PRL mRNA expression in the MtT/F4 transplantable tumor.
在F344雌性大鼠中分析了17β-雌二醇（E2）对MtT/F4垂体肿瘤生长以及催乳素（PRL）和生长激素mRNA表达的影响。E2（10毫克）刺激垂体PRL细胞增生和PRL mRNA，但抑制可移植肿瘤的生长。MtT/F4肿瘤中PRL和生长激素mRNA水平均升高。与肿瘤相比，E2对垂体中PRL mRNA水平升高的影响更为显著。这些结果表明，雌激素刺激垂体中的细胞增殖和PRL表达，同时抑制MtT/F4肿瘤中的细胞增殖。E2还刺激了MtT/F4可移植肿瘤中生长激素和PRL mRNA的表达。
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