脂联素与N末端脑钠肽前体独立相关：动脉粥样硬化的多民族研究。
Adiponectin is independently associated with NT-proBNP: The Multi-Ethnic Study of Atherosclerosis.
作者信息
Allison M A, Criqui M H, Maisel A S, Daniels L B, Roberts C K, Polak J F, Cushman M
机构信息
Department of Family and Preventive Medicine, University of California San Diego, La Jolla, CA, USA.
Department of Family and Preventive Medicine, University of California San Diego, La Jolla, CA, USA.
出版信息
Nutr Metab Cardiovasc Dis. 2015 Aug;25(8):780-6. doi: 10.1016/j.numecd.2015.04.005. Epub 2015 Apr 25.
BACKGROUND AND AIMS
To investigate the associations between selected adipokines and the N-terminal prohormone of B-type natriuretic peptide (NT-proBNP).
METHODS AND RESULTS
As many as 1489 individuals enrolled in the Multi-Ethnic Study of Atherosclerosis were evaluated at 4 clinic visits about every 2 years. The evaluation included fasting venous blood, which was analyzed for NT-proBNP (at visits 1 and 3) and the adipokines adiponectin and leptin (at visits 2 and 3). The mean age was 64.8 ± 9.6 years and 48% were female. After multivariable adjustment, a 1-SD increment in adiponectin was associated with a 14 pg/ml higher NT-proBNP level (p < 0.01), while, compared to the 1st quartile of adiponectin, the 2nd, 3rd and 4th quartiles had 28, 45 and 67% higher NT-proBNP levels (p < 0.01 for all). For changes in NT-proBNP over the follow-up period, and after multivariable adjustment including baseline NT-proBNP, a 1-SD increment in adiponectin was associated with a 25 pg/ml absolute increase in NT-proBNP (p < 0.01), while those in the 2nd, 3rd and 4th quartiles of adiponectin were associated with increases of 5, 28 and 65 pg/ml (p = 0.74, 0.09 and <0.01, respectively). There was a significant interaction between adiponectin and sex for visit 3 NT-proBNP (p-interaction < 0.01), with significantly stronger associations in men. Leptin was not associated with NT-proBNP.
CONCLUSION
Higher adiponectin, but not leptin, is significantly associated with higher levels of NT-proBNP, as well as with greater longitudinal increases in NT-proBNP. The associations were stronger in men.
背景与目的
研究特定脂肪因子与B型利钠肽原N端前体（NT-proBNP）之间的关联。
方法与结果
多达1489名参与动脉粥样硬化多民族研究的个体，每2年接受4次临床访视评估。评估包括空腹静脉血，用于分析NT-proBNP（在第1次和第3次访视时）以及脂肪因子脂联素和瘦素（在第2次和第3次访视时）。平均年龄为64.8±9.6岁，48%为女性。多变量调整后，脂联素每增加1个标准差与NT-proBNP水平升高14 pg/ml相关（p<0.01），而与脂联素第1四分位数相比，第2、3和4四分位数的NT-proBNP水平分别高28%、45%和67%（均p<0.01）。对于随访期间NT-proBNP的变化，在包括基线NT-proBNP的多变量调整后，脂联素每增加1个标准差与NT-proBNP绝对增加25 pg/ml相关（p<0.01），而脂联素第2、3和4四分位数的个体与NT-proBNP增加5、28和65 pg/ml相关（分别为p = 0.74、0.09和<0.01）。第3次访视时NT-proBNP在脂联素与性别之间存在显著交互作用（交互作用p<0.01），在男性中的关联显著更强。瘦素与NT-proBNP无关。
结论
较高的脂联素而非瘦素与较高的NT-proBNP水平以及NT-proBNP更大的纵向增加显著相关。这些关联在男性中更强。
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