针对癌症干细胞的化疗。
Chemotherapy targeting cancer stem cells.
作者信息
Liu Haiguang, Lv Lin, Yang Kai
机构信息
Department of Surgical Oncology, The First Affiliated Hospital of Wenzhou Medical University Fuxue Road No. 2, Wenzhou, 325000, China ; Department of Pathology, Southern Hospital of Southern Medical University Guangzhou Road No. 1838, Guangzhou, 510515, China.
Department of Surgical Oncology, The First Affiliated Hospital of Wenzhou Medical University Fuxue Road No. 2, Wenzhou, 325000, China.
出版信息
Am J Cancer Res. 2015 Feb 15;5(3):880-93. eCollection 2015.
Conventional chemotherapy is the main treatment for cancer and benefits patients in the form of decreased relapse and metastasis and longer overall survival. However, as the target therapy drugs and delivery systems are not wholly precise, it also results in quite a few side effects, and is less efficient in many cancers due to the spared cancer stem cells, which are considered the reason for chemotherapy resistance, relapse, and metastasis. Conventional chemotherapy limitations and the cancer stem cell hypothesis inspired our search for a novel chemotherapy targeting cancer stem cells. In this review, we summarize cancer stem cell enrichment methods, the search for new efficient drugs, and the delivery of drugs targeting cancer stem cells. We also discuss cancer stem cell hierarchy complexity and the corresponding combination therapy for both cancer stem and non-stem cells. Learning from cancer stem cells may reveal novel strategies for chemotherapy in the future.
传统化疗是癌症的主要治疗方法，其能够降低复发和转移几率，并延长患者的总生存期，从而使患者受益。然而，由于靶向治疗药物和递送系统并非完全精准，传统化疗也会产生不少副作用，并且在许多癌症中，由于癌症干细胞的存在，其疗效较低，而癌症干细胞被认为是化疗耐药、复发和转移的原因。传统化疗的局限性以及癌症干细胞假说促使我们去寻找一种针对癌症干细胞的新型化疗方法。在这篇综述中，我们总结了癌症干细胞富集方法、新型高效药物的探索以及针对癌症干细胞的药物递送。我们还讨论了癌症干细胞层级结构的复杂性以及针对癌症干细胞和非干细胞的相应联合治疗方法。从癌症干细胞中汲取经验教训可能会为未来的化疗揭示新的策略。
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