不同暴露场景下焊工的癌症风险评估
Cancer Risk Assessment in Welder's Under Different Exposure Scenarios.
作者信息
Barkhordari Abolfazl, Zare Sakhvidi Mohammad Javad, Zare Sakhvidi Fariba, Halvani Gholamhossein, Firoozichahak Ali, Shirali GholamAbbas
机构信息
1. Dept. of Occupational Health, Faculty of Health, Shahid Sadoughi University of Medical Sciences , Yazd, Iran.
2. Dept. of Occupational Health Engineering, School of Public Health, Ahvaz Jundishapur University of Medical Sciences , Iran.
出版信息
Iran J Public Health. 2014 May;43(5):666-73.
BACKGROUND
Welders exposure to nickel and hexavalent chromium in welding fumes is associated with increase of cancer risk in welders. In this study we calculated cancer risk due to exposure to these compounds in welders.
METHODS
The role of exposure parameters in welders on derived incremental lifetime cancer risk were determined by stochastic modeling of cancer risk. Input parameters were determined by field investigation in Iranian welders in 2013 and literature review.
RESULTS
The 90% upper band cancer risk due to hexavalent chromium and nickel exposure was in the range of 6.03E-03 to 2.12E-02 and 7.18E-03 to 2.61E-02 respectively. Scenario analysis showed that asthmatic and project welders are significantly at higher cancer risk in comparison with other welders (P<0.05). Shift duration was responsible for 37% and 33% of variances for hexavalent chromium and nickel respectively.
CONCLUSIONS
Welders are at high and unacceptable risk of cancer. Control measures according to scenario analysis findings are advisable.
背景
焊工在焊接烟尘中接触镍和六价铬与患癌风险增加有关。在本研究中，我们计算了焊工接触这些化合物所致的患癌风险。
方法
通过对癌症风险进行随机建模，确定焊工接触参数对推导的终生癌症增量风险的作用。输入参数通过2013年对伊朗焊工的现场调查及文献综述来确定。
结果
因接触六价铬和镍所致的90%上限癌症风险分别在6.03E-03至2.12E-02以及7.18E-03至2.61E-02范围内。情景分析表明，与其他焊工相比，哮喘焊工和项目焊工的患癌风险显著更高（P<0.05）。轮班时长分别占六价铬和镍所致差异的37%和33%。
结论
焊工面临着高且不可接受的癌症风险。根据情景分析结果采取控制措施是可取的。
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