Sports Medicine Section, Duke University Medical Center, Durham, NC, USA.
Cartilage. 2012 Jan;3(1 Suppl):69S-76S. doi: 10.1177/1947603511408287.
Osteoarthritis of the knee is a complex interaction of biological, mechanical, and biochemical factors that are further complicated by injury, which accelerates pathological processes within the joint. As a result, athletes, particularly those with a history of knee injury, have an earlier onset and higher prevalence of osteoarthritis that would be expected based on their age. This can present a clinical dilemma to the physician managing the patient who, despite the presence of radiologically confirmed disease, has few symptoms and wishes to maintain an active lifestyle.
We reviewed meta-analyses and systematic reviews of randomized controlled trials about clinical management of knee osteoarthritis with special interest on effect sizes.
Numerous management options have undergone the rigor of clinical trials and subsequently have been summarized in meta-analyses and systematic reviews, the results of which offer evidence regarding varying degrees of effect. Based on the available evidence, most summaries and clinical practice guidelines suggest a regimen of patient education, self-management, weight control, and exercise supported by individualized pain management strategies. Other noninvasive or less invasive strategies are available that have varying degrees of effect.
Although the evidence supporting many of the clinical management options might be considered modest, those effects are sufficient to permit an active lifestyle and have, given the prevalence of the disease, a public health impact.
膝关节骨关节炎是一个复杂的生物、机械和生化因素相互作用的结果,受伤会加速关节内的病理过程,使情况变得更为复杂。因此,运动员,尤其是那些有膝关节受伤史的运动员,其骨关节炎的发病更早、患病率更高,超过了基于年龄的预期。这给管理患者的医生带来了临床难题,尽管患者存在放射学确诊的疾病,但症状很少,希望保持积极的生活方式。
我们回顾了关于膝关节骨关节炎临床管理的荟萃分析和系统评价,特别关注效应量。
许多管理选择都经过了临床试验的严格检验,随后在荟萃分析和系统评价中进行了总结,这些结果提供了关于不同程度效果的证据。根据现有证据,大多数总结和临床实践指南建议采用患者教育、自我管理、体重控制和运动的方案,并辅以个体化的疼痛管理策略。还有其他非侵入性或侵入性较小的策略,其效果也不同。
尽管许多临床管理选择的证据可能被认为是适度的,但这些效果足以允许患者保持积极的生活方式,并且考虑到该疾病的流行程度,对公共健康也有影响。