Yamamoto T, Yasuda J, Kanao M, Okada H
Department of Obstetrics and Gynecology, Kyoto Prefectural, University of Medicine.
Jpn J Antibiot. 1989 Oct;42(10):2121-7.
Clinical studies on cefodizime (THR-221, CDZM), a new injectable cephem antibiotic, were performed and the following results were obtained. Ten patients with obstetrical and gynecological infections such as intrauterine infections, pyometra, adnexitis, parametritis and lymphocystitis. The clinical results were evaluated as excellent in 1 case, good in 4 cases and poor in 5 cases. The efficacy rate was 50.0%. Bacteriologically, 10 organisms were isolated from 8 patients and the eradication rate was 44.4%. No side effects were observed in any of the cases treated with CDZM. In laboratory examinations, transient elevations of serum GOT, GPT and Al-P were noted in 1 case.
对新型注射用头孢菌素类抗生素头孢地嗪(THR - 221,CDZM)进行了临床研究,获得了以下结果。10例患有妇产科感染的患者,如宫内感染、子宫积脓、附件炎、子宫旁组织炎和淋巴囊肿炎。临床结果评估为:1例优,4例良,5例差。有效率为50.0%。细菌学方面,从8例患者中分离出10株病原体,根除率为44.4%。使用CDZM治疗的任何病例均未观察到副作用。实验室检查中,1例患者血清谷草转氨酶、谷丙转氨酶和碱性磷酸酶出现短暂升高。