来自光叶桑的新型异戊烯基化酚类化合物。
New Isoprenylated Phenolic Compounds from Morus laevigata.
作者信息
Wang Meng, Yu Bang-Wei, Yu Mei-Hua, Gao Li-Xin, Li Jing-Ya, Wang He-Yao, Li Jia, Hou Ai-Jun
机构信息
Department of Pharmacognosy, School of Pharmacy, Fudan University, 826 Zhang Heng Road, Shanghai 201203, P. R. China (phone/fax: +86-21-51980005).
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, P. R. China.
出版信息
Chem Biodivers. 2015 Jun;12(6):937-45. doi: 10.1002/cbdv.201400210.
Two new isoprenylated flavonoids, laevigasins A and B (1 and 2, resp.), and one new isoprenylated 2-arylbenzofuran, leavigasin C (3), together with eight known compounds, 4-11, were isolated from the twigs of Morus laevigata. Their structures were elucidated by spectroscopic methods. Laevigasin A (1) showed significant inhibitory effect on α-glucosidase in vitro. Notabilisin E (5), taxifolin (10), and hultenin (11) inhibited PTP1B phosphatase activity in vitro.
从鸡桑嫩枝中分离得到两个新的异戊烯基黄酮类化合物，分别为左桑素A和B（1和2），以及一个新的异戊烯基2-芳基苯并呋喃，左桑素C（3），同时还得到了8个已知化合物，4-11。通过光谱方法对它们的结构进行了鉴定。左桑素A（1）在体外对α-葡萄糖苷酶显示出显著的抑制作用。诺塔比菌素E（5）、 taxifolin（10）和hultenin（11）在体外抑制蛋白酪氨酸磷酸酶1B（PTP1B）的活性。
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