Ogura Takeshi, Yamamoto Kazuhiro, Sano Tatsushi, Onda Saori, Imoto Akira, Masuda Daisuke, Takagi Wataru, Fukunishi Shinya, Higuchi Kazuhide
2nd Department of Internal Medicine, Osaka Medical College, Osaka, Japan.
Department of Radiology, Osaka Medical College, Osaka, Japan.
J Gastroenterol Hepatol. 2015 Dec;30(12):1748-52. doi: 10.1111/jgh.13021.
Despite high technical and functional success rates with endoscopic ultrasound-guided hepaticogastrostomy (EUS-HGS), rates of adverse events have also been high. No reports have focused on EUS-HGS alone with a large sample size about predictors of stent patency. The present study examined predictors of stent patency in patients who underwent EUS-HGS.
The consecutive 51 patients who underwent EUS-HGS using one metallic stent were retrospectively enrolled in this study. Baseline characteristics, stent length from the hepatic portion and in the luminal portion, kinds of stent dysfunction, and stent patency were reviewed.
Median duration of stent patency was significantly shorter with stent length in the luminal portion <3 cm (52 days) than with ≥3 cm (195 days; P < 0.01). On the other hand, median duration of stent patency did not differ significantly between ≥4 cm (194 days) and <4 cm (127 days; P = 0.1726). Length of stent in the luminal portion ≥3 cm (Hazard ration [HR], 9.242; 95% confidence interval [CI], 3.255-26.244, P < 0.05) and performance of chemotherapy (HR, 3.022; 95% CI, 1.448-6.304, P < 0.05) were also associated with long stent patency on the Cox proportional hazards model.
In conclusion, to obtain long-term stent patency, our data suggest that a stent length ≥3 cm in the luminal portion may be suitable for EUS-HGS.
尽管内镜超声引导下肝胃吻合术(EUS-HGS)在技术和功能上成功率较高,但不良事件发生率也较高。尚无关于单纯EUS-HGS且样本量较大的支架通畅性预测因素的报道。本研究探讨了接受EUS-HGS患者的支架通畅性预测因素。
本研究回顾性纳入了连续51例接受单枚金属支架EUS-HGS的患者。回顾了基线特征、肝段和腔内段支架长度、支架功能障碍类型以及支架通畅情况。
腔内段支架长度<3 cm时,支架通畅的中位持续时间(52天)显著短于≥3 cm时(195天;P<0.01)。另一方面,腔内段支架长度≥4 cm(194天)和<4 cm(127天)时,支架通畅的中位持续时间差异无统计学意义(P=0.1726)。在Cox比例风险模型中,腔内段支架长度≥3 cm(风险比[HR],9.242;95%置信区间[CI],3.255-26.244,P<0.05)和化疗的实施(HR,3.022;95%CI,1.448-6.304,P<0.05)也与支架长期通畅相关。
总之,为获得长期的支架通畅性,我们的数据表明腔内段支架长度≥3 cm可能适用于EUS-HGS。