Smith Mark E B, Caspersen Mikael B, Robinson Eifion, Morais Maurício, Maruani Antoine, Nunes João P M, Nicholls Karl, Saxton Malcolm J, Caddick Stephen, Baker James R, Chudasama Vijay
Department of Chemistry, University College London, London, WC1H 0AJ, UK.
Org Biomol Chem. 2015 Aug 7;13(29):7946-9. doi: 10.1039/c5ob01205h. Epub 2015 Jun 25.
Herein we report the use of bromomaleimides for the construction of stable albumin conjugates via conjugation to its native, single accessible, cysteine followed by hydrolysis. Advantages over the classical maleimide approach are highlighted in terms of quantitative hydrolysis and absence of undesirable retro-Michael deconjugation.
在此，我们报道了通过与天然的、单个可及的半胱氨酸共轭然后水解，使用溴马来酰亚胺构建稳定的白蛋白缀合物。在定量水解和不存在不期望的逆迈克尔去共轭方面，突出了相对于经典马来酰亚胺方法的优势。
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