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基于证据的慢性牙周炎非手术治疗临床实践指南:采用龈上洁治和根面平整术(有无辅助治疗)

Evidence-based clinical practice guideline on the nonsurgical treatment of chronic periodontitis by means of scaling and root planing with or without adjuncts.

作者信息

Smiley Christopher J, Tracy Sharon L, Abt Elliot, Michalowicz Bryan S, John Mike T, Gunsolley John, Cobb Charles M, Rossmann Jeffrey, Harrel Stephen K, Forrest Jane L, Hujoel Philippe P, Noraian Kirk W, Greenwell Henry, Frantsve-Hawley Julie, Estrich Cameron, Hanson Nicholas

出版信息

J Am Dent Assoc. 2015 Jul;146(7):525-35. doi: 10.1016/j.adaj.2015.01.026.

Abstract

BACKGROUND

A panel of experts convened by the American Dental Association Council on Scientific Affairs presents an evidence-based clinical practice guideline on nonsurgical treatment of patients with chronic periodontitis by means of scaling and root planing (SRP) with or without adjuncts.

METHODS

The authors developed this clinical practice guideline according to the American Dental Association's evidence-based guideline development methodology. This guideline is founded on a systematic review of the evidence that included 72 research articles providing clinical attachment level data on trials of at least 6 months' duration and published in English through July 2014. The strength of each recommendation (strong, in favor, weak, expert opinion for, expert opinion against, and against) is based on an assessment of the level of certainty in the evidence for the treatment's benefit in combination with an assessment of the balance between the magnitude of the benefit and the potential for adverse effects.

PRACTICAL IMPLICATIONS AND CONCLUSIONS

For patients with chronic periodontitis, SRP showed a moderate benefit, and the benefits were judged to outweigh potential adverse effects. The authors voted in favor of SRP as the initial nonsurgical treatment for chronic periodontitis. Although systemic subantimicrobial-dose doxycycline and systemic antimicrobials showed similar magnitudes of benefits as adjunctive therapies to SRP, they were recommended at different strengths (in favor for systemic subantimicrobial-dose doxycycline and weak for systemic antimicrobials) because of the higher potential for adverse effects with higher doses of antimicrobials. The strengths of 2 other recommendations are weak: chlorhexidine chips and photodynamic therapy with a diode laser. Recommendations for the other local antimicrobials (doxycycline hyclate gel and minocycline microspheres) were expert opinion for. Recommendations for the nonsurgical use of other lasers as SRP adjuncts were limited to expert opinion against because there was uncertainty regarding their clinical benefits and benefit-to-adverse effects balance. Note that expert opinion for does not imply endorsement but instead signifies that evidence is lacking and the level of certainty in the evidence is low.

摘要

背景

由美国牙科协会科学事务委员会召集的一组专家提出了一项基于证据的临床实践指南,内容涉及通过龈下刮治术和根面平整术(SRP)(有无辅助治疗)对慢性牙周炎患者进行非手术治疗。

方法

作者根据美国牙科协会基于证据的指南制定方法制定了本临床实践指南。本指南基于对证据的系统评价,该评价纳入了72篇研究文章,这些文章提供了至少为期6个月试验的临床附着水平数据,并于2014年7月前以英文发表。每项建议的强度(强烈支持、支持、弱支持、专家支持意见、专家反对意见和反对)基于对治疗益处证据确定性水平的评估,同时结合对益处大小与潜在不良反应之间平衡的评估。

实际意义和结论

对于慢性牙周炎患者,SRP显示出中度益处,且益处被判定超过潜在不良反应。作者投票支持将SRP作为慢性牙周炎的初始非手术治疗方法。尽管全身使用亚抗菌剂量强力霉素和全身使用抗菌药物作为SRP辅助治疗显示出相似程度的益处,但由于高剂量抗菌药物有更高的潜在不良反应风险,它们的推荐强度不同(全身使用亚抗菌剂量强力霉素为支持,全身使用抗菌药物为弱支持)。另外两项建议的强度较弱:洗必泰薄片和二极管激光光动力疗法。对其他局部抗菌药物(盐酸多西环素凝胶和米诺环素微球)的推荐为专家支持意见。对其他激光作为SRP辅助治疗的非手术使用的推荐仅限于专家反对意见,因为其临床益处以及益处与不良反应平衡存在不确定性。请注意,专家支持意见并不意味着认可,而是表明缺乏证据且证据的确定性水平较低。

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