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颅外颈动脉动脉瘤的处理。

Management of extracranial carotid artery aneurysm.

机构信息

Department of Vascular Surgery, University Medical Center Utrecht, Utrecht, The Netherlands.

Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.

出版信息

Eur J Vasc Endovasc Surg. 2015 Aug;50(2):141-7. doi: 10.1016/j.ejvs.2015.05.002. Epub 2015 Jun 24.

Abstract

INTRODUCTION

Aneurysms of the extracranial carotid artery (ECAA) are rare. Several treatments have been developed over the last 20 years, yet the preferred method to treat ECAA remains unknown. This paper is a review of all available literature on the risk of complications and long-term outcome after conservative or invasive treatment of patients with ECAA.

METHODS

Reports on ECAA treatment until July 2014 were searched in PubMed and Embase using the key words aneurysm, carotid, extracranial, and therapy.

RESULTS

A total of 281 articles were identified. Selected articles were case reports (n = 179) or case series (n = 102). Papers with fewer than 10 patients were excluded, resulting in the final selection of 39 articles covering a total of 1,239 patients. Treatment consisted of either conservative treatment in 11% of the cases or invasive treatment in 89% of the cases. Invasive treatment comprised surgery in 94%, endovascular approach in 5%, and a hybrid approach in 1% of the patients. The most common complication described after invasive therapy was cranial nerve damage, which occurred in 11.8% of patients after surgery. The 30 day mortality rate and stroke rate in conservatively treated patients was 4.67% and 6.67%, after surgery 1.91% and 5.16%. Information on confounders in the present study was incomplete. Therefore, adjustments to correct for confounding by indication could not be done.

CONCLUSIONS

This review summarizes the largest available series in the literature on ECAA management. The number of ECAAs reported in current literature is scarce. The early and long-term outcome of invasive treatment in ECAA is favorable; however, cranial nerve damage after surgery occurs frequently. Unfortunately, due to limitations in reporting of results and confounding by indication in the available literature, it was not possible to determine the optimal treatment strategy. There is a need for a multicenter international registry to reveal the optimal treatment for ECAA.

摘要

介绍

颅外颈动脉动脉瘤(ECAA)较为罕见。在过去的 20 年中,已经开发了几种治疗方法,但治疗 ECAA 的首选方法仍不清楚。本文综述了所有关于 ECAA 患者保守或介入治疗后并发症风险和长期预后的可用文献。

方法

使用关键词动脉瘤、颈动脉、颅外和治疗,在 PubMed 和 Embase 中搜索截至 2014 年 7 月的 ECAA 治疗报告。

结果

共确定了 281 篇文章。选择的文章为病例报告(n=179)或病例系列(n=102)。排除了少于 10 例患者的文章,最终选择了 39 篇文章,共涵盖了 1239 例患者。治疗方法包括保守治疗(11%)或介入治疗(89%)。介入治疗包括手术(94%)、血管内治疗(5%)和杂交治疗(1%)。描述的最常见的并发症是手术后颅神经损伤,发生率为 11.8%。保守治疗患者的 30 天死亡率和卒中率分别为 4.67%和 6.67%,手术治疗后分别为 1.91%和 5.16%。本研究中混杂因素的信息不完整。因此,无法进行调整以纠正适应证混杂。

结论

本文综述了目前文献中关于 ECAA 管理的最大系列研究。目前文献报道的 ECAA 数量较少。ECAA 介入治疗的早期和长期预后良好,但手术后颅神经损伤发生率较高。遗憾的是,由于现有文献中结果报告的局限性和适应证混杂,无法确定最佳治疗策略。需要一个多中心国际登记处来揭示 ECAA 的最佳治疗方法。

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