癌症与恶病质中的微小RNA——一篇综述短文
MicroRNA in Cancer and Cachexia--A Mini-Review.
作者信息
Acunzo Mario, Croce Carlo M
机构信息
Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University Comprehensive Cancer Center, Columbus.
出版信息
J Infect Dis. 2015 Jul 15;212 Suppl 1(Suppl 1):S74-7. doi: 10.1093/infdis/jiv197.
Abstract
MicroRNAs (miRNAs) are short noncoding RNAs with a length of approximately 22 nucleotides that are involved in posttranscriptional regulation of gene expression. miRNAs cover an important role in all biological processes, and aberrant miRNA expression is commonly associated with cancer. Recent discoveries have associated the involvement of miRNA in an increasingly large number of biological processes, including cachexia. The cachexia syndrome is a debilitating state of cancer that is, at least in part, associated with apoptosis. The mechanism through which tumors promote the characteristic distal loss of muscle and fat mass during the cachectic process is still not deeply investigated. In this review, we briefly describe the role of miRNAs in cancer development and cachexia.
摘要
微小RNA（miRNA）是一类长度约为22个核苷酸的短链非编码RNA，参与基因表达的转录后调控。miRNA在所有生物学过程中都发挥着重要作用，其表达异常通常与癌症相关。最近的研究发现，miRNA参与了越来越多的生物学过程，包括恶病质。恶病质综合征是癌症导致的一种使人衰弱的状态，至少部分与细胞凋亡有关。肿瘤在恶病质过程中促使肌肉和脂肪大量进行性丢失的机制仍未得到深入研究。在本综述中，我们简要描述了miRNA在癌症发展和恶病质中的作用。
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