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血管内栓塞治疗盆腔淤血综合征的疗效评估——初步研究

Evaluation of effectiveness of endovascular embolisation for the treatment of pelvic congestion syndrome--preliminary study.

作者信息

Pyra Krzysztof, Woźniak Sławomir, Roman Tomasz, Czuczwar Piotr, Trojanowska Agnieszka, Jargiełło Tomasz, Paszkowski Tomasz

出版信息

Ginekol Pol. 2015 May;86(5):346-51. doi: 10.17772/gp/2420.

Abstract

OBJECTIVES

The Aim: The aim of the study was to evaluate the effectiveness, safety and clinical outcomes of endovascular embolisation of pelvic congestion syndrome (PCS).

MATERIAL AND METHODS

This prospective, observational study carried out between January and May of 2014 encompassed 24 female patients aged 22-44 years (average - 31 years) diagnosed with PCS. Diagnosis of PCS was established by medical history physical examination, transvaginal Doppler ultrasound examination and confirmed by MRI. The patients were qualified for phlebography and ovarian vein embolization with 0.035" detachable coils and/or microcoils. Pelvic pain scores were assessed before and 3 months after the procedure with the visual analog scale (VAS; 0 - no pain, 10 - unbearable pain).

RESULTS

Embolisation procedures were performed in 23 out of 24 patients. Nineteen patients underwent unilateral and 4 patients bilateral embolisation of the ovarian vein. In one case, safe and selective vessel catheterization was not possible due to the anatomical variant of venous flow. Nineteen patients underwent unilateral embolisation of the left ovarian vein. Four patients had the left and right ovarian veins embolized; in one of them, the internal iliac vein was additionally closed (the two-stage procedure). The technical success rate was 96%. Procedures lasted 23-78 minutes (32 minutes on average). An average of 40 ml of contrast was administered during the procedures. The total mean radiation dose at the reference point was 389 mGy (from 127 mGy to 1112 mGy). A decrease in pelvic pain intensity according to VAS was considered a clinical success. The median VAS pelvic pain score before the procedure was 8. Three months after the procedure median pelvic pain score decreased to 1 (p < 0.001). In two cases, the ovarian vein was injured and the contrast medium extravasated, which was clinically insignificant. In one case, a small injection site haematoma developed.

CONCLUSION

Embolisation is a minimally invasive, effective and safe method of treatment for PCS. The cooperation between gynaecologists and interventional radiologists is essential for successful outcomes.

摘要

目的

本研究旨在评估盆腔淤血综合征(PCS)血管内栓塞治疗的有效性、安全性及临床疗效。

材料与方法

本前瞻性观察性研究于2014年1月至5月进行,纳入了24例年龄在22 - 44岁(平均31岁)诊断为PCS的女性患者。PCS的诊断通过病史、体格检查、经阴道多普勒超声检查并经MRI确诊。患者符合静脉造影及使用0.035英寸可脱性弹簧圈和/或微弹簧圈进行卵巢静脉栓塞的条件。术前及术后3个月采用视觉模拟评分法(VAS;0 - 无痛,10 - 难以忍受的疼痛)评估盆腔疼痛评分。

结果

24例患者中有23例进行了栓塞治疗。19例患者接受了单侧卵巢静脉栓塞,4例患者接受了双侧卵巢静脉栓塞。1例因静脉血流解剖变异无法进行安全、选择性血管插管。19例患者接受了左侧卵巢静脉单侧栓塞。4例患者双侧卵巢静脉均进行了栓塞;其中1例额外封闭了髂内静脉(分两阶段进行)。技术成功率为96%。手术持续时间为23 - 78分钟(平均32分钟)。手术过程中平均注入40毫升造影剂。参考点处的总平均辐射剂量为389毫戈瑞(范围为127毫戈瑞至1112毫戈瑞)。根据VAS评估盆腔疼痛强度降低被视为临床成功。术前盆腔疼痛VAS评分中位数为8分。术后3个月盆腔疼痛评分中位数降至1分(p < 0.001)。2例出现卵巢静脉损伤及造影剂外渗,但临床意义不大。1例出现小的注射部位血肿。

结论

栓塞是治疗PCS的一种微创、有效且安全的方法。妇科医生与介入放射科医生之间的合作对于取得成功的治疗效果至关重要。

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