纤毛：心脏病的核心器官。

Cilia: Organelles at the Heart of Heart Disease.

机构信息

Institute of Molecular and Cell Biology, Proteos, 61 Biopolis Drive, Singapore 138673.

Institute of Molecular and Cell Biology, Proteos, 61 Biopolis Drive, Singapore 138673; Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, Singapore; Department of Pediatrics, National University of Singapore, 1E Kent Ridge Drive, Singapore.

出版信息

Curr Biol. 2015 Jun 29;25(13):R559-62. doi: 10.1016/j.cub.2015.05.005.

DOI:10.1016/j.cub.2015.05.005

PMID:26126281

Abstract

Genetic disorders, such as heterotaxy, first provided a link between cilia and developmental heart defects. Now, a genetic screen in mice shows that ciliary dysfunction may indeed be the major contributing factor in the etiology of congenital heart disease.

摘要

遗传性疾病，如心脏异位，首次将纤毛与心脏发育缺陷联系起来。如今，一项在小鼠身上进行的基因筛查显示，纤毛功能障碍确实可能是先天性心脏病病因学中的主要致病因素。