层状结构与胶束结构——一种用于非病毒多核苷酸转运的三链阳离子脂质的聚集行为

Lamellar versus Micellar Structures-Aggregation Behavior of a Three-Chain Cationic Lipid Designed for Nonviral Polynucleotide Transfer.

作者信息

Wölk Christian, Janich Christopher, Pawlowska Dorota, Drescher Simon, Meister Annette, Hause Gerd, Dobner Bodo, Langner Andreas, Brezesinski Gerald

机构信息

Martin Luther University Halle-Wittenberg, Institute of Pharmacy, Wolfgang-Langenbeck-Straße 4, 06120 Halle (Saale) (Germany).

Max Planck Institute of Colloids and Interfaces, Am Mühlenberg 1, 14476 Potsdam (Germany).

出版信息

Chemphyschem. 2015 Jul 20;16(10):2029. doi: 10.1002/cphc.201500468. Epub 2015 Jun 30.

DOI:10.1002/cphc.201500468

PMID:26129690

Abstract

The front cover artwork is provided by the groups of Prof. Bodo Dobner, Prof. Andreas Langner, and research partners Dr. Gerd Hause, Dr. Simon Drescher, and Dr. Annette Meister (MLU Halle-Wittenberg) as well as the group of Prof. Gerald Brezesinski (MPI of Colloids and Interfaces). The image shows the space-filling model of a three-chain amino-functionalized lipid designed for gene transfer and the preferred pH-dependent aggregates (multilamellar stacks, vesicles, rod-like micelles). The background shows a Cryo-TEM image of rod-like micelles. Read the full text of the article at 10.1002/cphc.201500188.

摘要

封面插图由博多·多布纳教授、安德烈亚斯·朗纳教授的团队以及研究伙伴格尔德·豪斯博士、西蒙·德雷舍尔博士和安妮特·迈斯特博士（哈雷 - 维滕贝格马丁路德大学）以及杰拉尔德·布雷泽辛斯基教授（胶体与界面马克斯·普朗克研究所）提供。该图像展示了一种为基因转移设计的三链氨基功能化脂质的空间填充模型以及优选的pH依赖性聚集体（多层堆叠、囊泡、棒状胶束）。背景展示了棒状胶束的冷冻透射电子显微镜图像。可在10.1002/cphc.201500188阅读该文章全文。