白细胞介素-17A对正常条件下及逐渐拉伸过程中大鼠心房心肌生物电活动的影响。
Effects of interleukin-17A on the bioelectric activity of rat atrial myocardium under normal conditions and during gradual stretching.
作者信息
Ovchinnikov R S, Mitrokhin V M, Mladenov M I
机构信息
Department of Fundamental and Applied Physiology, Russian National Research Medical University, Ostrovitjanova 1, Moscow 117997, Russia; Federal Scientific Clinical Center for Specialized Types of Medical Assistance and Medical Technologies of the Federal Medical and Biological Agency, Orekhoviy Boulevard 28, Moscow 115682, Russia.
Department of Fundamental and Applied Physiology, Russian National Research Medical University, Ostrovitjanova 1, Moscow 117997, Russia.
出版信息
Cytokine. 2015 Dec;76(2):561-565. doi: 10.1016/j.cyto.2015.06.016. Epub 2015 Jul 4.
Using microelectrode technique we studied the effects of interleukin-17A on the activity of rat atrial myocardium under normal conditions and after gradual stretching of the tissue. Perfusion with interleukin-17A for 35 min without stretch, led to an increase in APD25, APD50 and APD90. The effect on the frequency and force of the contraction was absent. Stretching during interleukin-17A perfusion led to an increase only at the level of APD90. In the same condition, the repetition frequency of the action potentials did not change as well. Close observation of the cytokine induced mechanisms, confirmed that IL-17A act on different levels and induce different signaling pathways involved in the regulation of cardiac function.
我们使用微电极技术研究了白细胞介素-17A在正常条件下以及组织逐渐拉伸后对大鼠心房心肌活性的影响。在无拉伸情况下用白细胞介素-17A灌注35分钟，导致APD25、APD50和APD90增加。对收缩频率和力量没有影响。在白细胞介素-17A灌注期间进行拉伸仅导致APD90水平升高。在相同条件下，动作电位的重复频率也没有变化。对细胞因子诱导机制的密切观察证实，IL-17A作用于不同水平并诱导参与心脏功能调节的不同信号通路。
Zotero 插件