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Eculizumab treatment efficiently prevents C5 cleavage without C5a generation in vivo.

作者信息

Volokhina Elena B, Bergseth Grethe, van de Kar Nicole C A J, van den Heuvel Lambertus P, Mollnes Tom Eirik

机构信息

Department of Pediatric Nephrology, Radboud University Medical Center, Nijmegen, The Netherlands.

Research Laboratory, Nordland Hospital, Bodø, Norway.

出版信息

Blood. 2015 Jul 9;126(2):278-9. doi: 10.1182/blood-2015-03-637645.

Abstract
摘要

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Eculizumab treatment during pregnancy does not affect the complement system activity of the newborn.
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Eculizumab fails to inhibit generation of C5a in vivo.
Blood. 2014 Nov 27;124(23):3502-3. doi: 10.1182/blood-2014-07-589366.
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An international serum standard for application in assays to detect human complement activation products.
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Thrombin generates previously unidentified C5 products that support the terminal complement activation pathway.
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