血清催乳素水平升高作为寻常型银屑病中炎症性关节炎的标志物。

Elevated serum prolactin levels as a marker of inflammatory arthritis in psoriasis vulgaris.

作者信息

Husakova Marketa, Lippert Jan, Stolfa Jiri, Sedova Liliana, Arenberger Petr, Lacinova Zdenka, Pavelka Karel

机构信息

Institute of Rheumatology, Na Slupi 4, 12850 Prague 2, Czech Republic.

Department of Dermatology, Stadt. Klinikum Gorlitz, Girbingsdorfer Strasse 1-3, Gorlitz, Germany.

出版信息

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2015 Dec;159(4):562-8. doi: 10.5507/bp.2015.033. Epub 2015 Jul 10.

DOI:10.5507/bp.2015.033

PMID:26175050

Abstract

BACKGROUND AND AIMS

Psoriasis vulgaris (PV) is complicated in up to 40% patients by the inflammatory joint disease psoriatic arthritis (PsA). Neither the aetiology of the arthritis nor specific laboratory markers for its disease activity have been clearly elucidated. Prolactin (PRL) acts as a cytokine with immunomodulatory functions and plays a role in skin and joint biology. The results on PRL however as a marker are unclear. The aim of this study was to confirm whether serum PRL levels reflect systemic complications of PV, like inflammatory joint disease and/or can serve as a marker of disease activity in both cases.

METHODS

A total of 70 patients with PV without arthritis and 40 patients suffering from PsA were included. In all patients, we determined skin disease activity according to the PASI index and in PsA, active disease assessed as swollen or tender joints. The control group included 27 age and sex matched healthy individuals. The concentration of PRL in the serum was measured by immunoradiometric assays.

RESULTS

The PRL serum levels were significantly increased in PsA patients (299.2±28.29 mIU/L) compared to PV only patients (201.4.2±11.72 mIU/L), P = 0.0003 and healthy individuals (198.2±15.31 mIU/L), P = 0.007. The serum PRL levels in PsA with active disease 336.8±42.50 (mIU/L) were higher than in PV and controls, P < 0.0001 and P = 0.002 respectively. In PV only patients, there was no correlation between PASI and PRL levels.

CONCLUSION

Our results showed that PRL serum levels are a marker of active arthritis in PsA and reflects systemic complication rather than local skin activity.

摘要

背景与目的

高达40%的寻常型银屑病（PV）患者会并发炎性关节病银屑病关节炎（PsA）。关节炎的病因及其疾病活动的特异性实验室标志物均尚未明确阐明。催乳素（PRL）作为一种具有免疫调节功能的细胞因子，在皮肤和关节生物学中发挥作用。然而，PRL作为一种标志物的结果尚不清楚。本研究的目的是确认血清PRL水平是否反映PV的全身并发症，如炎性关节病，和/或在这两种情况下是否可作为疾病活动的标志物。

方法

共纳入70例无关节炎的PV患者和40例PsA患者。在所有患者中，我们根据银屑病面积和严重程度指数（PASI）确定皮肤疾病活动度，在PsA患者中，将疾病活动评估为关节肿胀或压痛。对照组包括27名年龄和性别匹配的健康个体。采用免疫放射分析法测定血清中PRL的浓度。

结果

与仅患PV的患者（201.4±11.72 mIU/L）相比，PsA患者的PRL血清水平显著升高（299.2±28.29 mIU/L），P = 0.0003；与健康个体（198.2±15.31 mIU/L）相比，P = 0.007。疾病活动的PsA患者的血清PRL水平为336.8±42.50（mIU/L），高于PV患者和对照组，分别为P < 0.0001和P = 0.002。在仅患PV的患者中，PASI与PRL水平之间无相关性。