根据肿瘤体积，18F-FDG PET/CT的SUVmax在甲状腺良恶性结节鉴别诊断中的应用
SUVmax of 18F-FDG PET/CT in the differential diagnosis of benign and malignant thyroid nodules according to tumor volume.
作者信息
Kim Tae Heon, Ji Yong Bae, Song Chang Myeon, Kim Ji Young, Choi Yun Young, Park Jeong Seon, Tae Kyung
机构信息
Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Hanyang University, 222 Wangsimni-ro, Seongdong-gu, Seoul, 133-792, Korea.
Department of Nuclear Medicine, College of Medicine, Hanyang University, Seoul, Korea.
出版信息
World J Surg Oncol. 2015 Jul 16;13:217. doi: 10.1186/s12957-015-0635-1.
BACKGROUND
The aim of this study was to investigate whether the maximum standardized uptake value (SUVmax) measured on fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) could be used as the primary means of differential diagnosis of thyroid nodules when tumor volume is assessed.
METHODS
We studied 192 patients who underwent preoperative 18F-FDG PET/CT followed by thyroidectomy. We evaluated the correlation between the volume of thyroid nodules, 18F-FDG uptake on visual analysis, and the mean SUVmax measured on 18F-FDG PET/CT.
RESULTS
When stratified by tumor volume, the mean SUVmax was higher in malignant than in benign nodules in nodules≥1 cm3 (p<0.001). However, it did not differ between benign and malignant nodules smaller than 1 cm3. At a cut-off value of SUVmax of 6, the respective sensitivities of 18F-FDG PET/CT, ultrasonography, and fine needle aspiration cytology were 60.8, 96.4, and 99.1%, and the respective specificities were 95.9, 98.2, and 96.8%.
CONCLUSIONS
18F-FDG PET/CT is limited as a primary modality in the differential diagnosis of benign and malignant thyroid nodules because of its low sensitivity.
背景
本研究旨在探讨在评估肿瘤体积时，氟-18氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描（18F-FDG PET/CT）测量的最大标准化摄取值（SUVmax）是否可作为甲状腺结节鉴别诊断的主要手段。
方法
我们研究了192例术前行18F-FDG PET/CT检查随后接受甲状腺切除术的患者。我们评估了甲状腺结节体积、18F-FDG视觉分析摄取情况以及18F-FDG PET/CT测量的平均SUVmax之间的相关性。
结果
按肿瘤体积分层时，≥1 cm3的结节中，恶性结节的平均SUVmax高于良性结节（p<0.001）。然而，小于1 cm3的良性和恶性结节之间平均SUVmax无差异。SUVmax临界值为6时，18F-FDG PET/CT、超声检查和细针穿刺细胞学检查的敏感性分别为60.8%、96.4%和99.1%，特异性分别为95.9%、98.2%和96.8%。
结论
18F-FDG PET/CT由于其低敏感性，在甲状腺良恶性结节鉴别诊断中作为主要手段存在局限性。
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