表观基因组数据发布：一种以参与者为中心的隐私保护方法。
Epigenome data release: a participant-centered approach to privacy protection.
作者信息
Dyke Stephanie O M, Cheung Warren A, Joly Yann, Ammerpohl Ole, Lutsik Pavlo, Rothstein Mark A, Caron Maxime, Busche Stephan, Bourque Guillaume, Rönnblom Lars, Flicek Paul, Beck Stephan, Hirst Martin, Stunnenberg Henk, Siebert Reiner, Walter Jörn, Pastinen Tomi
机构信息
Centre of Genomics and Policy, Department of Human Genetics, McGill University, Montreal, QC, H3A 0G1, Canada.
Department of Human Genetics, McGill University and Genome Quebec Innovation Centre, Montreal, QC, H3A 0G1, Canada.
出版信息
Genome Biol. 2015 Jul 17;16(1):142. doi: 10.1186/s13059-015-0723-0.
Large-scale epigenome mapping by the NIH Roadmap Epigenomics Project, the ENCODE Consortium and the International Human Epigenome Consortium (IHEC) produces genome-wide DNA methylation data at one base-pair resolution. We examine how such data can be made open-access while balancing appropriate interpretation and genomic privacy. We propose guidelines for data release that both reduce ambiguity in the interpretation of open-access data and limit immediate access to genetic variation data that are made available through controlled access.
美国国立卫生研究院表观基因组学路线图计划、DNA元件百科全书计划（ENCODE）以及国际人类表观基因组联盟（IHEC）开展的大规模表观基因组图谱绘制工作，以单碱基对分辨率生成了全基因组DNA甲基化数据。我们探讨了如何在平衡适当解读和基因组隐私的同时，使这些数据能够开放获取。我们提出了数据发布指南，既减少开放获取数据解读中的模糊性，又限制对通过受控访问提供的遗传变异数据的直接访问。
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