来自吉祥草的甾体苷类。
Steroidal glycosides from Reineckia carnea.
作者信息
Song Xiaomei, Zhang Dongdong, He Hao, Li Yuze, Yang Xinjie, Deng Chong, Tang Zhishu, Cui Jiucheng, Yue Zhenggang
机构信息
Shaanxi Collaborative Innovation Center of Chinese Medicinal Resource Industrialization, Shaanxi Province Key Laboratory of New Drugs and Chinese Medicine Foundation Research, Shaanxi Rheumatism and Tumor Center of TCM Engineering Technology Research, School of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang 712046, China.
School of Pharmaceutical Sciences, Xi'an Medical University, Xi'an 710021, China.
出版信息
Fitoterapia. 2015 Sep;105:240-5. doi: 10.1016/j.fitote.2015.07.008. Epub 2015 Jul 15.
Three new steroidal glycosides (1-3) and a novel natural product 4 firstly obtained from a plant source, together with two known steroidal glycosides (5-6) have been isolated from the whole plant of Reineckia carnea. Their structures were determined by physicochemical properties and spectroscopic methods, and their cytotoxic activities against human 1299 tumor cells were evaluated by the MTT method. Compounds 4, 5 and 6 exhibited cytotoxicity with IC50 values of 50.3 μmol·L(-1), 67.2 μmol·L(-1) and 61.8 μmol·L(-1), while compounds 1, 2, and 3 showed no cytotoxicity with the cells.
从吉祥草全株中分离得到了三种新的甾体苷（1-3）、一种首次从植物来源获得的新型天然产物4以及两种已知的甾体苷（5-6）。通过理化性质和光谱方法确定了它们的结构，并采用MTT法评估了它们对人1299肿瘤细胞的细胞毒性活性。化合物4、5和6表现出细胞毒性，IC50值分别为50.3 μmol·L(-1)、67.2 μmol·L(-1)和61.8 μmol·L(-1)，而化合物1、2和3对这些细胞没有细胞毒性。
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