服用兰索拉唑6年后出现胶原性结肠炎。

Collagenous colitis appeared after 6-year administration of lansoprazole.

作者信息

Sawada Koji, Fujiya Mikihiro, Itabashi Kentaro, Suzuki Yasuyuki, Kubo Koji, Nata Toshie, Ueno Nobuhiro, Inaba Yuhei, Moriichi Kentaro, Okamoto Kotaro, Ikuta Katsuya, Tanabe Hiroki, Mizukami Yusuke, Takagi Yoshitake, Kohgo Yutaka

机构信息

Department of Internal Medicine, Municipal Nakashibetsu Hospital, Nakashibetsu, Japan.

Division of Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical College, 2-1 Midorigaoka-higashi, Asahikawa, Hokkaido, 078-8510, Japan.

出版信息

Clin J Gastroenterol. 2010 Feb;3(1):18-21. doi: 10.1007/s12328-009-0126-4. Epub 2009 Nov 28.

DOI:10.1007/s12328-009-0126-4

PMID:26189901

Abstract

Collagenous colitis (CC) is one of the causes of undefined watery diarrhea, which is histologically accompanied by thickening of the subepithelial collagen layer. CC associated with lansoprazole normally occurs within several weeks after initial administration, but no case presenting after long-term administration of lansoprazole has yet been reported. A 77-year-old male with 6-year history of administration of lansoprazole complained of watery diarrhea and weight loss. Colonoscopy revealed disappearance of vascular networks and red spots in the sigmoid colon. Biopsy specimen showed erosion and collagen bands thickened, so the patient was diagnosed as CC. After lansoprazole discontinuation, the watery diarrhea disappeared and histological abnormalities improved.

摘要

胶原性结肠炎（CC）是不明原因水样腹泻的病因之一，其组织学特征为上皮下胶原层增厚。与兰索拉唑相关的CC通常在首次给药后的几周内发生，但长期服用兰索拉唑后出现病例的情况尚未见报道。一名有6年兰索拉唑用药史的77岁男性，出现水样腹泻和体重减轻。结肠镜检查显示乙状结肠血管网消失和红斑。活检标本显示有糜烂和胶原带增厚，因此该患者被诊断为CC。停用兰索拉唑后，水样腹泻消失，组织学异常得到改善。