取代芪对血小板功能的影响。

Effect of substituted stilbenes on platelet function.

作者信息

Messina Federica, Guglielmini Giuseppe, Curini Massimo, Orsini Sara, Gresele Paolo, Marcotullio Maria Carla

机构信息

Department of Pharmaceutical Sciences, Section of Public Health, University of Perugia, via del, Liceo, 1, 06123 Perugia, Italy.

Department of Medicine, Section of Internal and Cardiovascular Medicine, University of Perugia, via E. dal Pozzo, 06126 Perugia, Italy.

出版信息

Fitoterapia. 2015 Sep;105:228-33. doi: 10.1016/j.fitote.2015.07.009. Epub 2015 Jul 18.

DOI:10.1016/j.fitote.2015.07.009

PMID:26197385

Abstract

Stilbenes, including resveratrol, are polyphenols provided with protective actions on the cardiovascular system. Some natural derivatives of resveratrol, like pterostilbene, have a better bioavailability than the parent compound. The aim of the present study was to prepare different substituted stilbenes (dimethylallyloxy-stilbene, dimethylallyloxy-pterostilbene) and compare them with resveratrol, p-hydroxy-stilbene and pterostilbene for their biologic activities on platelet aggregation, platelet radical oxygen species (ROS) production, and platelet nitric oxide (NO) synthesis. The results show that the increase of stilbene derivative lipophilicity enhances their biologic activities.

摘要

包括白藜芦醇在内的芪类化合物是对心血管系统具有保护作用的多酚类物质。白藜芦醇的一些天然衍生物，如紫檀芪，比母体化合物具有更好的生物利用度。本研究的目的是制备不同取代的芪类化合物（二甲基烯丙氧基芪、二甲基烯丙氧基紫檀芪），并将它们与白藜芦醇、对羟基芪和紫檀芪在血小板聚集、血小板活性氧（ROS）生成及血小板一氧化氮（NO）合成方面的生物学活性进行比较。结果表明，芪类衍生物亲脂性的增加会增强其生物学活性。