宏观球模型——一种栓塞性中风模型，用于在转化研究方法中研究局灶性脑缺血的病理生理学。
The macrosphere model-an embolic stroke model for studying the pathophysiology of focal cerebral ischemia in a translational approach.
机构信息
1 Department of Neurology, University Hospital of Cologne, Cologne, Germany ; 2 Max-Planck-Institute for Metabolism Research, Cologne, Germany ; 3 Animal Welfare Office, University of Cologne, Germany.
出版信息
Ann Transl Med. 2015 Jun;3(9):123. doi: 10.3978/j.issn.2305-5839.2015.04.02.
The main challenge of stroke research is to translate promising experimental findings from the bench to the bedside. Many suggestions have been made how to achieve this goal, identifying the need for appropriate experimental animal models as one key issue. We here discuss the macrosphere model of focal cerebral ischemia in the rat, which closely resembles the pathophysiology of human stroke both in its acute and chronic phase. Key pathophysiological processes such as brain edema, cortical spreading depolarizations (CSD), neuroinflammation, and stem cell-mediated regeneration are observed in this stroke model, following characteristic temporo-spatial patterns. Non-invasive in vivo imaging allows studying the macrosphere model from the very onset of ischemia up to late remodeling processes in an intraindividual and longitudinal fashion. Such a design of pre-clinical stroke studies provides the basis for a successful translation into the clinic.
脑卒中研究的主要挑战是将有前途的实验发现从实验室转化到临床。已经提出了许多建议来实现这一目标，其中确定需要适当的实验动物模型是一个关键问题。我们在这里讨论大鼠局灶性脑缺血的大球体模型，该模型在其急性和慢性阶段均非常类似于人类脑卒中的病理生理学。在这种脑卒中模型中，可以观察到关键的病理生理过程，如脑水肿、皮质扩散性去极化（CSD）、神经炎症和干细胞介导的再生，它们具有特征性的时空模式。非侵入性的体内成像可以在个体内和纵向的方式研究从缺血开始到晚期重塑过程中的大球体模型。这种临床前脑卒中研究的设计为成功转化为临床提供了基础。
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