Jing Dian, Hao Jin, Shen Yu, Tang Ge, Li Mei-Le, Huang Shi-Hu, Zhao Zhi-He
State Key Laboratory of Oral Diseases, Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Department of Orthopaedics and Traumatology, The University of Hong Kong, Hong Kong, China.
Int J Oral Sci. 2015 Sep 14;7(3):131-43. doi: 10.1038/ijos.2015.22.
Bone remodeling is balanced by bone formation and bone resorption as well as by alterations in the quantities and functions of seed cells, leading to either the maintenance or deterioration of bone status. The existing evidence indicates that microRNAs (miRNAs), known as a family of short non-coding RNAs, are the key post-transcriptional repressors of gene expression, and growing numbers of novel miRNAs have been verified to play vital roles in the regulation of osteogenesis, osteoclastogenesis, and adipogenesis, revealing how they interact with signaling molecules to control these processes. This review summarizes the current knowledge of the roles of miRNAs in regulating bone remodeling as well as novel applications for miRNAs in biomaterials for therapeutic purposes.
骨重塑通过骨形成和骨吸收以及种子细胞数量和功能的改变而达到平衡，从而导致骨状态的维持或恶化。现有证据表明，微小RNA（miRNA）作为一类短链非编码RNA，是基因表达的关键转录后抑制因子，越来越多的新型miRNA已被证实在成骨、破骨细胞生成和脂肪生成的调节中发挥重要作用，揭示了它们如何与信号分子相互作用以控制这些过程。本文综述了目前关于miRNA在调节骨重塑中的作用的知识，以及miRNA在治疗用生物材料中的新应用。
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