圆锥新香薷的抗菌成分。

Antibacterial constituents of Neohyptis paniculata.

作者信息

Rahman M Mukhlesur, Gibbons Simon

机构信息

Department of Pharmaceutical and Biological Chemistry, UCL School of Pharmacy, 29-39 Brunswick Square, London WC1N 1AX, UK; Medicine Research Group, School of Health, Sport and Bioscience, University of East London, Stratford Campus, Water Lane, London E15 4LZ, UK.

Department of Pharmaceutical and Biological Chemistry, UCL School of Pharmacy, 29-39 Brunswick Square, London WC1N 1AX, UK.

出版信息

Fitoterapia. 2015 Sep;105:269-72. doi: 10.1016/j.fitote.2015.07.012. Epub 2015 Jul 21.

DOI:10.1016/j.fitote.2015.07.012

PMID:26208955

Abstract

A new α-pyrone, 6R-[5R,6S-diacetyloxy-1Z,3E-heptadienyl]-5,6-dihydro-2H-pyran-2one (1), along with six known compounds including an α-pyrone, flavones and terpenes was isolated from the aerial parts of Neohyptis paniculata. The structure of 1 was established unambiguously by MS and a series of 1D and 2D-NMR spectroscopic analyses. The antibacterial activity of the compounds (1-7) was investigated against five strains of multi-drug resistant (MDR) and methicillin-resistant Staphylococcus aureus and minimum inhibitory concentrations (MICs) of these compounds were found to be in the range of 64-256 μg/mL.

摘要

从圆锥新香薷的地上部分分离得到一种新的α-吡喃酮，即6R-[5R,6S-二乙酰氧基-1Z,3E-庚二烯基]-5,6-二氢-2H-吡喃-2-酮（1），以及六种已知化合物，包括一种α-吡喃酮、黄酮类化合物和萜类化合物。通过质谱以及一系列一维和二维核磁共振光谱分析明确确定了1的结构。研究了化合物（1-7）对五株耐多药（MDR）和耐甲氧西林金黄色葡萄球菌菌株的抗菌活性，发现这些化合物的最低抑菌浓度（MIC）在64-256μg/mL范围内。