在高脂饮食诱导的肥胖胰岛素抵抗动物中，血游离脂肪酸并未增加。
Blood free fatty acids were not increased in high-fat diet induced obese insulin-resistant animals.
作者信息
Jiang Junfeng, Wu Yongjie, Wang Xiaoxia, Lu Li, Wang Li, Zhang Baolai, Cui Mingxia
机构信息
Institute of Pharmacology, School of Basic Medical Science, Lanzhou University, Key Laboratory of Preclinical Study for New Drugs of Gansu Province, Lanzhou, China; Gansu Provincial Cancer Hospital, Lanzhou, China.
Institute of Pharmacology, School of Basic Medical Science, Lanzhou University, Key Laboratory of Preclinical Study for New Drugs of Gansu Province, Lanzhou, China.
出版信息
Obes Res Clin Pract. 2016 Mar-Apr;10(2):207-10. doi: 10.1016/j.orcp.2015.06.005. Epub 2015 Jul 22.
OBJECTIVE
The close connection between high blood FFA and insulin resistance (IR) in obese individuals is well-known. The purpose of this study was to identify whether the blood FFA increased in obese-IR animals.
METHODS
Obese-IR animal models were established using high-fat diet (HFD) or HFD and streptozocin, and treated with drugs.
RESULTS
The serum FFA of obese-IR animals was not increased, even significantly lower than that of normal animals, and were not significantly decreased when insulin sensitivity and obesity-related indices were ameliorated after treatment.
CONCLUSION
The results suggest that blood FFA are unlikely the link between obesity and insulin resistance.
目的
肥胖个体中血液游离脂肪酸（FFA）与胰岛素抵抗（IR）之间的密切联系已为人熟知。本研究的目的是确定肥胖-胰岛素抵抗动物的血液FFA是否升高。
方法
使用高脂饮食（HFD）或HFD联合链脲佐菌素建立肥胖-胰岛素抵抗动物模型，并进行药物治疗。
结果
肥胖-胰岛素抵抗动物的血清FFA并未升高，甚至显著低于正常动物，且在治疗后胰岛素敏感性和肥胖相关指标改善时也未显著降低。
结论
结果表明血液FFA不太可能是肥胖与胰岛素抵抗之间的联系环节。
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