轴性近视与原发性开角型青光眼的视野预后相关。
Axial Myopia Is Associated with Visual Field Prognosis of Primary Open-Angle Glaucoma.
作者信息
Qiu Chen, Qian Shaohong, Sun Xinghuai, Zhou Chuandi, Meng Fanrong
机构信息
Department of Ophthalmology, Eye and Ear, Nose, Throat Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
Department of Ophthalmology, Eye and Ear, Nose, Throat Hospital, Shanghai Medical College, Fudan University, Shanghai, China; State Key Laboratory of Medical Neurobiology, Institutes of Brain Science, Fudan University, Shanghai, China; Key Laboratory of Myopia, Ministry of Health (Fudan University), Shanghai, China; Shanghai Key Laboratory of Visual Impairment and Restoration (Fudan University), Shanghai, China.
出版信息
PLoS One. 2015 Jul 27;10(7):e0133189. doi: 10.1371/journal.pone.0133189. eCollection 2015.
PURPOSE
To identify whether myopia was associated with the visual field (VF) progression of primary open-angle glaucoma (POAG).
METHODS
A total of 270 eyes of 270 POAG followed up for more than 3 years with ≥9 reliable VFs by Octopus perimetry were retrospectively reviewed. Myopia was divided into: mild myopia (-2.99 diopter [D], 0), moderate myopia (-5.99, 3.00 D), marked myopia (-9.00, -6.00 D) and non-myopia (0 D or more). An annual change in the mean defect (MD) slope >0.22 dB/y and 0.30 dB/y was defined as fast progression, respectively. Logistic regression was performed to determine prognostic factors for VF progression.
RESULTS
For the cutoff threshold at 0.22 dB/y, logistic regression showed that vertical cup-to-disk ratio (VCDR; p = 0.004) and the extent of myopia (p = 0.002) were statistically significant. When logistic regression was repeated after excluding the extent of myopia, axial length (AL; p = 0.008, odds ratio [OR] = 0.796) reached significance, as did VCDR (p = 0.001). Compared to eyes with AL≤23 mm, the OR values were 0.334 (p = 0.059), 0.309 (p = 0.044), 0.266 (p = 0.019), 0.260 (p = 0.018), respectively, for 23 <AL≤24 mm, 24 <AL≤25 mm, 25 <AL ≤26 mm, and AL>26 mm. The significance of vertical cup-to-disk ratio of (p = 0.004) and the extent of myopia (p = 0.008) did not change for the cutoff threshold at 0.30dB/y.
CONCLUSIONS
VCDR and myopia were associated with VF prognosis of POAG. Axial myopia may be a protective factor against VF progression.
目的
确定近视是否与原发性开角型青光眼（POAG）的视野（VF）进展相关。
方法
回顾性分析270例POAG患者的270只眼，这些患者随访时间超过3年，通过Octopus视野计获得≥9次可靠的视野检查结果。近视分为：轻度近视（-2.99屈光度[D]，0）、中度近视（-5.99，-3.00 D）、高度近视（-9.00，-6.00 D）和非近视（0 D或更高）。平均缺损（MD）斜率每年变化>0.22 dB/y和>0.30 dB/y分别定义为快速进展。进行逻辑回归以确定VF进展的预后因素。
结果
对于截断阈值为0.22 dB/y，逻辑回归显示垂直杯盘比（VCDR；p = 0.004）和近视程度（p = 0.002）具有统计学意义。在排除近视程度后重复进行逻辑回归时，眼轴长度（AL；p = 0.008，比值比[OR]=0.796）以及VCDR（p = 0.001）具有统计学意义。与AL≤23 mm的眼相比，对于23 <AL≤24 mm、24 <AL≤25 mm、25 <AL≤26 mm和AL>26 mm的眼，OR值分别为0.334（p = 0.059）、0.309（p = 0.044）、0.266（p = 0.019）、0.
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