针对心脏代谢疾病的干扰素调节因子：机遇与挑战。
Targeting Interferon Regulatory Factor for Cardiometabolic Diseases: Opportunities and Challenges.
机构信息
Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, China.
Center for Animal Experiment/ ABSL-III Laboratory of Wuhan University, Wuhan 430060, China.
出版信息
Curr Drug Targets. 2017;18(15):1754-1778. doi: 10.2174/1389450116666150804110412.
BACKGROUND
The pathological activation of innate immune system may contribute to the development of cardiometabolic diseases. The interferon regulatory factor (IRF) family members, which are the major transcription factors in innate immune signaling, are implicated in cardiometabolic diseases.
OBJECTIVE
The aim of this review is to summary the current knowledge of the biological functions of IRFs in innate immune responses and immune cell development, and highlight our contemporary understanding of the functions and molecular mechanisms of IRFs in metabolic diseases, cardiovascular remodeling, and stroke.
RESULTS
IRFs are the essential regulators of cardiometabolic diseases via immune-dependent and - independent manners.
CONCLUSION
IRFs signaling is the promising target to manage the initiation and progression of cardiometabolic disorders.
背景
先天免疫系统的病理性激活可能导致代谢性心血管疾病的发生。干扰素调节因子 (IRF) 家族成员是先天免疫信号转导中的主要转录因子，它们与代谢性心血管疾病有关。
目的
本综述旨在总结 IRF 在先天免疫反应和免疫细胞发育中的生物学功能的现有知识，并强调我们对 IRF 在代谢性疾病、心血管重塑和中风中的功能和分子机制的当代理解。
结果
IRF 通过免疫依赖和非依赖的方式成为代谢性心血管疾病的重要调节因子。
结论
IRF 信号是管理代谢性心血管疾病发生和进展的有前途的靶点。
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