Al-Daghri Nasser M, Al-Attas Omar S, Wani Kaiser, Alnaami Abdullah M, Sabico Shaun, Al-Ajlan Abdulrahman, Chrousos George P, Alokail Majed S
Biomarkers Research Program, Biochemistry Department, College of Science, King Saud University, Riyadh, 11451, Kingdom of Saudi Arabia.
Prince Mutaib Bin Abdullah Chair on Osteoporosis, Biochemistry Department, College of Science, King Saud University, PO Box, 2455, Riyadh, 11451, Kingdom of Saudi Arabia.
Cardiovasc Diabetol. 2015 Aug 7;14:101. doi: 10.1186/s12933-015-0265-5.
Obesity is a recognized risk factor for various cardiometabolic diseases and several indices are used clinically to assess overall cardiometabolic risk. This study aims to determine the sensitivity of six anthropometric indices [Body mass index (BMI), waist, waist-to-hip ratio (WHR), waist-to-height ratio (WHtR), body adiposity index (BAI) and visceral adiposity index (VAI)] in determining diabetes mellitus type 2, coronary heart disease, dyslipidemia, hypertension and metabolic syndrome (MetS) in Saudi adults recruited from two independent cohorts (2008-2009 and 2013-2014).
A total of 6,821 Saudi adults [2008-2009, N = 3,971 (1,698 males and 2,273 females); 2013-2014, N = 2,850 (926 males and 1,924 females)] aged 18-70 years old were included in this descriptive, cross-sectional study. Anthropometrics were obtained and fasting blood samples analyzed for glucose and lipids. BMI, WHR, WHtR, BAI and VAI were computed mathematically.
VAI was the most sensitive index in determining DMT2 (AUC 0.72; p < 0.001) in the 2008-2009 cohort and MetS (AUC = 0.84; p < 0.001) in the 2013-2014 cohort. WHR was most discriminating for CHD in both cohorts (AUC 0.70 and 0.84 for 2008-2009 and 2013-2014, p values <0.001, respectively). WHtR was most sensitive but rather modest in determining hypertension (AUC 0.66; p < 0.001), while waist circumference was most sensitive for dyslipidemia (AUC 0.72; p < 0.001) in the 2008-2009 cohort and MetS (AUC 0.85; p < 0.001) in the 2013-2014 cohort. BAI was the least sensitive adiposity index.
Sensitivity of adiposity indices regarding cardiometabolic diseases highlight the importance of body fat distribution in determining overall cardiometabolic risk, with indices involving abdominal obesity being more clinically significant than BMI and BAI. The sensitivity of these adiposity indices should be noted in assessing a particular cardiometabolic disease.
肥胖是多种心血管代谢疾病公认的风险因素，临床上使用多种指标来评估总体心血管代谢风险。本研究旨在确定六个身体测量指标[体重指数（BMI）、腰围、腰臀比（WHR）、腰高比（WHtR）、身体脂肪指数（BAI）和内脏脂肪指数（VAI）]在确定从两个独立队列（2008 - 2009年和2013 - 2014年）招募的沙特成年人患2型糖尿病、冠心病、血脂异常、高血压和代谢综合征（MetS）方面的敏感性。
本描述性横断面研究纳入了总共6821名年龄在18至70岁的沙特成年人[2008 - 2009年，N = 3971（1698名男性和2273名女性）；2013 - 2014年，N = 2850（926名男性和1924名女性）]。获取人体测量数据，并对空腹血样进行葡萄糖和脂质分析。通过数学计算得出BMI、WHR、WHtR、BAI和VAI。
在2008 - 2009年队列中，VAI是确定2型糖尿病（AUC 0.72；p < 0.001）最敏感的指标，在2013 - 2014年队列中是确定代谢综合征（AUC = 0.84；p < 0.001）最敏感的指标。在两个队列中，WHR对冠心病的区分能力最强（2008 - 2009年和2013 - 2014年的AUC分别为0.70和0.84，p值均<0.001）。WHtR在确定高血压方面最敏感但程度一般（AUC 0.66；p < 0.001），而在2008 - 2009年队列中，腰围对血脂异常最敏感（AUC 0.72；p < 0.001），在2013 - 2014年队列中对代谢综合征最敏感（AUC 0.85；p < 0.001）。BAI是最不敏感的身体脂肪指数。
肥胖指标对心血管代谢疾病的敏感性凸显了身体脂肪分布在确定总体心血管代谢风险中的重要性，涉及腹部肥胖的指标比BMI和BAI在临床上更具意义。在评估特定心血管代谢疾病时应注意这些肥胖指标的敏感性。
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