κ-卡拉胶对双重改性西米淀粉流变性能的影响：寻找硬胶囊用明胶替代品。
Effects of κ-carrageenan on rheological properties of dually modified sago starch: Towards finding gelatin alternative for hard capsules.
机构信息
Food Biopolymer Research Group, Food Science and Technology Department, Damghan Branch, Islamic Azad University, Damghan, Semanan, Iran.
Department of Biological Science, Damghan Branch, Islamic Azad University, Damghan, Semanan, Iran.
出版信息
Carbohydr Polym. 2015 Nov 5;132:156-63. doi: 10.1016/j.carbpol.2015.06.033. Epub 2015 Jun 19.
Composite sago starch-based system was developed and characterized with the aim to find an alternative to gelatin in the processing of pharmaceutical capsules. Dually modified (Hydrolyzed-Hydroxypropylated) sago starches were combined with κ-carrageenan (0.25, 0.5, 0.75, and 1%). The rheological properties of the proposed composite system were measured and compared with gelatin as reference material. Results show that combination of HHSS12 (Hydrolysed-hydroxypropylated sago starch at 12h) with 0.5% κ-carrageenan was comparable to gelatin rheological behavior in pharmaceutical capsule processing. The solution viscosity at 50 °C and sol-gel transition of the proposed composite system were comparable to those of gelatin. The viscoelastic moduli (G' and G") for the proposed system were lower than those of gelatin. These results illustrate that by manipulation of the constituents of sago starch-based composite system, a suitable alternative to gelatin can be produced with comparable properties and this could find potential application in pharmaceutical capsule industry.
开发了一种复合西米淀粉体系，旨在寻找明胶在制药胶囊加工中的替代品。双重改性（水解-羟丙基化）西米淀粉与κ-卡拉胶（0.25、0.5、0.75 和 1%）组合。测量了所提出的复合体系的流变性能，并与参考材料明胶进行了比较。结果表明，在制药胶囊加工中，将 HHSS12（12 小时水解-羟丙基化西米淀粉）与 0.5%κ-卡拉胶组合与明胶的流变行为相当。在 50°C 下溶液粘度和拟议复合体系的溶胶-凝胶转变与明胶相当。拟议体系的粘弹性模量（G'和 G"）低于明胶。这些结果表明，通过操纵西米淀粉基复合体系的成分，可以生产出具有可比性能的明胶替代品，这在制药胶囊行业可能具有潜在应用。
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