天然产物EBC - 329的全合成

Total synthesis of the natural product EBC-329.

作者信息

Thombal Raju S, Jadhav Vrushali H

机构信息

Division of Organic Chemistry, National Chemical Laboratory (CSIR-NCL), Pune-411008, India.

出版信息

Org Biomol Chem. 2015 Sep 28;13(36):9485-91. doi: 10.1039/c5ob01276g. Epub 2015 Aug 10.

DOI:10.1039/c5ob01276g

PMID:26256620

Abstract

The first total synthesis of an anti-leukemic diterpene natural product EBC-329 (1) has been accomplished starting from readily available 6,6-dimethyl-3-oxabicyclo[3.1.0]hexane-2,4-dione (7). An efficient and general approach has been reported for the synthesis of EBC-329 in 13 steps with an overall yield of 10%.

摘要

从易于获得的6,6 - 二甲基 - 3 - 氧杂双环[3.1.0]己烷 - 2,4 - 二酮（7）出发，首次完成了抗白血病二萜类天然产物EBC - 329（1）的全合成。已报道了一种高效通用的方法，以13步反应合成EBC - 329，总产率为10%。