结直肠癌中的体细胞基因拷贝数改变：对癌症驱动因素和生物标志物的新探索。
Somatic gene copy number alterations in colorectal cancer: new quest for cancer drivers and biomarkers.
作者信息
Wang H, Liang L, Fang J-Y, Xu J
机构信息
State Key Laboratory for Oncogenes and Related Genes; Key Laboratory of Gastroenterology & Hepatology, Ministry of Health; Division of Gastroenterology and Hepatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University; Shanghai Cancer Institute, Shanghai Institute of Digestive Disease, Shanghai, China.
出版信息
Oncogene. 2016 Apr 21;35(16):2011-9. doi: 10.1038/onc.2015.304. Epub 2015 Aug 10.
Colorectal cancer (CRC) results from the accumulation of genetic alterations, and somatic copy number alterations (CNAs) are crucial for the development of CRC. Genome-wide survey of CNAs provides opportunities for identifying cancer driver genes in an unbiased manner. The detection of aberrant CNAs may provide novel markers for the early diagnosis and personalized treatment of CRC. A major challenge in array-based profiling of CNAs is to distinguish the alterations that play causative roles from the random alterations that accumulate during colorectal carcinogenesis. In this view, we systematically discuss the frequent CNAs in CRC, focusing on functional genes that have potential diagnostic, prognostic and therapeutic significance.
结直肠癌（CRC）是由基因改变的积累所致，而体细胞拷贝数改变（CNA）对CRC的发展至关重要。全基因组CNA调查为以无偏倚的方式识别癌症驱动基因提供了机会。异常CNA的检测可为CRC的早期诊断和个性化治疗提供新的标志物。基于阵列的CNA分析中的一个主要挑战是区分在结直肠癌发生过程中起致病作用的改变与随机积累的改变。鉴于此，我们系统地讨论了CRC中常见的CNA，重点关注具有潜在诊断、预后和治疗意义的功能基因。
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