Luo Jing, Cui Wei, Ding Yu, Wang Binyan, Jiang Shanqun, Tang Genfu, Zang Tonghua, Qin Xianhui, Wang Yu, Wang Yi, Fan Fangfang, Zhang Yan, Li Jianping, Huo Yong, Xu Xiping
Institute of Biomedicine, Anhui Medicial University, Hefei 230032, China.
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Zhonghua Yu Fang Yi Xue Za Zhi. 2015 Mar;49(3):243-7.
To investigate the correlation between smoking status and carotid plaque in rural population residing in Eastern part of China.
Between July and September of 2013, an epidemiological survey was carried out in residents aged 40 or above men who were enrolled randomly in rural areas of Anqing, Anhui province and Lianyungang, Jiangsu province. The data on epidemiological characteristics including smoking status, physical examination were collected using standardized protocol, and carotid ultrasonography was applied to examine the incidence of carotid plaque among never smokers, former smokers and current smokers. Logistic regress analysis was performed to determine the effect of smoking on carotid plaque.
In the study, a total of 625 male participants were included in the study. 51.4% (321 cases) were current smokers, 21.3% (133 cases) were former smokers, and 27.4% (171 cases) were never smokers. 32.0% (200/625) had carotid plaque. The incidence of carotid plaques was significantly higher in current smokers (35.2%, 113/321) than that in never smokers(23.4%,40/171) (χ(2) = 7.26, P = 0.007) and the incidence in former smokers (35.3%, 47/133) was also higher than that in never smokers (23.4%, 40/171) (χ(2) = 5.23, P = 0.022). Multiple logistic regression analysis showed that current cigarette smoking is significantly associated with the increased risk of carotid plaque (OR = 1.84, 95% CI: 1.13-2.98, P = 0.014) in comparison with never smokers, and there was an interaction between current smoking and age in association with carotid plaque. Compared with the young (≤60 years old) and never smoking group (8%, 3/40), prevalence of carotid plaque among the elderly (>70 years old) and smoking group (55%, 31/56) was significantly higher (OR = 8.06, 95% CI: 2.07-31.45) after adjusting for age, systolic blood pressure, diastolic blood pressure, blood glucose, total cholesterol, triglyceride high-density lipoprotein, body mass index, drinking and regional differences.
It found that cigarette smoking was associated with increased risk of carotid plaque in rural elderly population residing in Eastern part of China.
探讨中国东部农村地区人群吸烟状况与颈动脉斑块之间的相关性。
2013年7月至9月，对安徽省安庆市和江苏省连云港市农村地区随机纳入的40岁及以上男性居民进行了一项流行病学调查。采用标准化方案收集包括吸烟状况、体格检查等在内的流行病学特征数据，并应用颈动脉超声检查从不吸烟者、既往吸烟者和当前吸烟者中颈动脉斑块的发生率。进行Logistic回归分析以确定吸烟对颈动脉斑块的影响。
本研究共纳入625名男性参与者。51.4%（321例）为当前吸烟者，21.3%（133例）为既往吸烟者，27.4%（171例）为从不吸烟者。32.0%（200/625）有颈动脉斑块。当前吸烟者中颈动脉斑块的发生率（35.2%，113/321）显著高于从不吸烟者（23.4%，40/171）（χ(2)=7.26，P = 0.007），既往吸烟者中颈动脉斑块的发生率（35.3%，47/133）也高于从不吸烟者（23.4%，40/171）（χ(2)=5.23，P = 0.022）。多因素Logistic回归分析显示，与从不吸烟者相比，当前吸烟与颈动脉斑块风险增加显著相关（OR = 1.84，95%CI：1.13 - 2.98，P = 0.014），并且当前吸烟与年龄在颈动脉斑块方面存在交互作用。调整年龄、收缩压、舒张压、血糖、总胆固醇、甘油三酯、高密度脂蛋白、体重指数、饮酒和地区差异后，与年轻（≤60岁）且从不吸烟组（8%，3/40）相比，老年（>70岁）且吸烟组中颈动脉斑块的患病率（55%，31/56）显著更高（OR = 8.06，95%CI：2.07 - 31.45）。
研究发现吸烟与中国东部农村老年人群颈动脉斑块风险增加有关。
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